Evidence map›Paper›PMID 39035425›Full record

ArticleIJTLD open2024

Severe outcomes among adults with TB during COVID-19.

T Jacobs, E Morden, M Smith, A von Delft, R Kassanjee, V Mudaly, A Boulle, M-A Davies

Abstract read
In one paragraph

Article in IJTLD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T JacobsHealth Intelligence Directorate, Western Cape Health and Wellness, Provincial Government of the Western Cape, Cape Town, South Africa.
E MordenHealth Intelligence Directorate, Western Cape Health and Wellness, Provincial Government of the Western Cape, Cape Town, South Africa.
M SmithHealth Intelligence Directorate, Western Cape Health and Wellness, Provincial Government of the Western Cape, Cape Town, South Africa.
A von DelftHealth Intelligence Directorate, Western Cape Health and Wellness, Provincial Government of the Western Cape, Cape Town, South Africa.
R KassanjeeSchool of Public Health, University of Cape Town, Cape Town, South Africa.
V MudalySchool of Public Health, University of Cape Town, Cape Town, South Africa.
A BoulleHealth Intelligence Directorate, Western Cape Health and Wellness, Provincial Government of the Western Cape, Cape Town, South Africa.
M-A DaviesHealth Intelligence Directorate, Western Cape Health and Wellness, Provincial Government of the Western Cape, Cape Town, South Africa.

Funding

Observational Antiretroviral Studies In Southern Africa (OASIS) CollaborationU01AI069924 · NIAID · UNIVERSITAT BERN · PI Cleophas Chimbetete, Mary-Ann Davies · 2006 to 2026
$55.9M
NIAID NIH HHS U01 AI069924Wellcome Trust
6 · The paper itself

Abstract

backgroundThe COVID-19 pandemic prompted strict public health measures to reduce SARS-CoV-2 transmission, potentially interrupting TB programmes in the Western Cape, South Africa.

methodsWe conducted a retrospective cohort study, estimating changes in new TB case rates and risk of death during TB-specific admissions within 6 months of TB first evidence, during the pre-pandemic (1 January 2019-26 March 2020) and after the implementation of public health and social measures (PHSM) periods (26 March 2020-30 September 2021), based on PHSM strictness. We used interrupted time series and logistic regression models to adjust for key characteristics.

resultsWe found an average 22% reduction (95% CI 19-25) in monthly TB cases during the entire PHSM implementation period. Additionally, the risk of death during TB-specific admissions increased, with the adjusted odds ratio ranging across PHSM levels from 1.36 (95% CI 1.17-1.57) on Level 1 to 1.44 (95% CI 1.16-1.79) on Level 2 compared with the pre-pandemic period.

conclusionsThere was a decline in the number of diagnosed TB cases and an increased risk of severe outcomes from 26 March 2020 to 30 September 2021 in the Western Cape. TB programme recovery strategies must be prioritised, and TB management programmes must be integrated into future pandemic responses.

Indexed as

outcomepandemic impactTB control

Identifiers

PMID39035425
PMCPMC11257091

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.