ReviewJournal of dental sciences2024
Interplay between diabetes mellitus and periodontal/pulpal-periapical diseases.
Review in Journal of dental sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between oral dysbiosis and Parkinson's disease: a systematic review.Frontiers in cellular and infection microbiology · 2025Pooled it
- Associations Between Systemic Diseases and Dental Pulp Diagnoses: A Retrospective Chart Study Using a Locally Deployed Large Language Model.Dentistry journal · 2026Article
- Gingival crevicular fluid levels of prolactin in periodontitis patients with controlled versus uncontrolled type 2 diabetes. a controlled clinical trial.Scientific reports · 2026Article
- Hypoglycemic and tissue protective effects of mangosteen (Garcinia mangostana L.) on diabetes associated periodontal tissue alterations.Odontology · 2026Article
- The relationship of apical periodontitis with chronic diseases and smoking habits: an umbrella review.Odontology · 2026Review
- Clinical characteristics and factors associated with dentition defects in patients with diabetes mellitus and concomitant endodontic disease.American journal of translational research · 2026Article
- A scientometric study on research trends and characteristics of diabetes-associated periodontal disease.Journal of dental sciences · 2026Article
- Oral health-related quality of life and diabetes outcomes: Evidence from a nationally representative U.S. sample.Journal of dental sciences · 2026Article
- Comparing Endodontic Treatment Prevalence in Diabetes Mellitus and Non-Diabetic Periodontitis Patients: A Retrospective Case-Control Investigation.International dental journal · 2025Article
- The Correlations Between Diabetes Mellitus and Oro-Maxillofacial Disorders: A Statistical Perspective.Dentistry journal · 2025Article
- DNA Methylation in Periodontal Disease: A Focus on Folate, Folic Acid, Mitochondria, and Dietary Intervention.International journal of molecular sciences · 2025Review
- Periodontal Disease in Saudi Arabia: A Systematic Review of Prevalence and Associated Risk Factors.Diagnostics (Basel, Switzerland) · 2025Review
- Knowledge of Antibiotic Management in Surgery, Periodontics and Endodontics Among Patients, Students and Dentistry Professors: A Cross-Sectional Study at the University of Barcelona (Spain).Journal of clinical medicine · 2025Article
- Periodontal therapy mitigates inflammation via TNF-α reduction and improves glycolipid metabolism in diabetic patients: a cross-sectional cohort study.Frontiers in endocrinology · 2025Article
- Periodontal inflammation potentially inhibits hepatic cytochrome P450 expression and disrupts the omega-3 epoxidation pathway in a murine model.Journal of dental sciences · 2025Article
- Impact of type 2 diabetes mellitus on the prevalence of apical periodontitis in endodontically treated and untreated teeth.Journal of medicine and life · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This longevity of life expectancy has indirectly led to an increase in the number of chronic diseases such as periodontitis, apical periodontitis (AP), and diabetes mellitus (DM) in the aging society, thus affecting people's quality of life. There is an interaction between periodontitis/AP and DM with a two-way relationship. Although type 1 and 2 diabetes (T1DM, T2DM) have different etiologies, glycemic control may affect the infection, inflammation and tissue healing of periodontitis and AP. Non-surgical periodontal treatment may influence the glycemic control as shown by decrease of HbA1c level in T2DM patient. However, the effect of periodontal treatment on glycemic control in T1DM and root canal treatment/apical surgery on T1DM and T2DM patients awaits investigation. DM may affect the periodontal and periapical tissues possibly via altered oral microbiota, impairment of neutrophils' activity and host immune responses and cytokine production, induction of oxidative stress etc. While periodontitis associated systemic inflammation and hyperlipidemia is suggested to contribute to the control of T2DM, more intricate studies are necessary to clarify the detailed mechanisms. The interactions between DM (T1DM and T2DM) and periodontitis and AP are therefore reviewed to provide a basis for the treatment of subsequent patients with pulpal/periodontal disease and diabetes. A two-pronged approach of medical and dental treatment is needed for the management of these patients, with emphasis on blood glucose control and improving oral hygiene and periodontal maintenance care, to ensure the best treatment outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.