Evidence map›Paper›PMID 39034428›Full record

Trial reportVascular and endovascular surgery2024

Axial Ablation versus Terminal Interruption of the Reflux Source (AAVTIRS): A Randomised Controlled Trial.

Keohane Cr, Westby D, Twyford M, Aherne T, Tawfick W, Walsh Sr

Registry-linked trialAbstract readComparative StudyRandomized Controlled TrialPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vascular and endovascular surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04484168 (Axial Ablation Versus Terminal Interruption of the Reflux Source), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04484168 naunknown statusnot on this map

Axial Ablation Versus Terminal Interruption of the Reflux Source (AAVTIRS): A Randomised Controlled Trial

TypeinterventionalSponsorUniversity College Hospital GalwayRan2020 to 2022Enrolled308ConditionsVenous UlcerArmsTerminal Interruption of the Reflux Source, Axial Ablation
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keohane CrNational University of Ireland Galway, Galway, Ireland.ORCID 0000-0002-8553-0865
Westby DNational University of Ireland Galway, Galway, Ireland.
Twyford MNational University of Ireland Galway, Galway, Ireland.
Aherne TNational University of Ireland Galway, Galway, Ireland.
Tawfick WNational University of Ireland Galway, Galway, Ireland.
Walsh SrNational University of Ireland Galway, Galway, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTreatment of reflux has been shown to improve time to healing of Venous Leg Ulcers (VLU). Terminal Interruption of the Reflux Source (TIRS) treats reflux within the plexus of veins around an active VLU using foam sclerotherapy. The efficacy of TIRS in managing VLU has never been tested.

methodsWe performed a pragmatic, single centre, assessor-blinded, randomised controlled trial comparing endovenous ablation of the axial superficial veins (Axial Ablation-AA) vs TIRS. Patients of any age with VLU of any duration were eligible.

results98 Participants were randomised to AA or TIRS. 39/55, 70.9% (95%CI; 57.1-82.37) healed their VLU in the AA group, while 29/39, 74.36% (95%CI; 57.87-86.96) healed their VLU in the TIRS group,

conclusionThe AAVTIRS trial did not show that axial ablation was superior to TIRS in the primary outcome of number of VLU healed in 6 months, or time to VLU healing. This trial is not powered to show non-inferiority. TIRS is a viable option for treatment of VLU. Further investigation is necessary before it can be recommended as an alternative to axial ablation.Trial registered at clinicaltrials.gov NCT04484168.

Indexed as

SclerotherapyVaricose UlcerWound HealingAblation TechniquesAgedEndovascular ProceduresFemaleHumansMaleMiddle AgedQuality of LifeSclerosing SolutionsTime FactorsTreatment OutcomeVenous InsufficiencySclerosing Solutionsendovenous ablationterminal interruption of the reflux sourcevenous leg ulcers

Identifiers

PMID39034428
PMCPMC11425978

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.