Evidence map›Paper›PMID 39034387›Full record

ReviewCancer cell international2024

Function of serine/arginine-rich splicing factors in hematopoiesis and hematopoietic malignancies.

Huifang Zhang, Hongkai Zhu, Hongling Peng, Yue Sheng

Abstract readReview
In one paragraph

Review in Cancer cell international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huifang ZhangDepartment of Hematology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, P. R. China. z2204140328@csu.edu.cn.
Hongkai ZhuDepartment of Hematology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, P. R. China.
Hongling PengDepartment of Hematology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, P. R. China. penghongling@csu.edu.cn.
Yue ShengDepartment of Hematology, the Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, P. R. China. shengyue@csu.edu.cn.

Funding

Huxiang Youth Talent Support Program 2022RC1205International Centre for Genetic Engineering and Biotechnology CRP/CHN22-03_ECNational Natural Science Foundation of China 82070175Scientific Research Project of Hunan Provincial Health Commission C202303046332the National Natural Science Foundation of China 32270791
6 · The paper itself

Abstract

The serine/arginine-rich splicing factors (SRSFs) play an important role in regulating the alternative splicing of precursor RNA (pre-RNA). During this procedure, introns are removed from the pre-RNA, while the exons are accurately joined together to produce mature mRNA. In addition, SRSFs also involved in DNA replication and transcription, mRNA stability and nuclear export, and protein translation. It is reported that SRSFs participate in hematopoiesis, development, and other important biological process. They are also associated with the development of several diseases, particularly cancers. While the basic physiological functions and the important roles of SRSFs in solid cancer have been extensively reviewed, a comprehensive summary of their significant functions in normal hematopoiesis and hematopoietic malignancies is currently absent. Hence, this review presents a summary of their roles in normal hematopoiesis and hematopoietic malignancies.

Indexed as

HematopoiesisHematopoietic malignanciesSerine/arginine-rich splicing factors

Identifiers

PMID39034387
PMCPMC11265194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.