Evidence map›Paper›PMID 39034374›Full record

ArticleImmunologic research2024

Regulation of Tert methylation alleviates food allergy via regulating the Tert-IL10 signal pathway.

Haotao Zeng, Lingzhi Xu, Jiangqi Liu, Lihua Mo, Minyao Li, Shuo Song, Xuejie Xu, Shihan Miao, Miao Zhao, Pingchang Yang

Abstract read
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Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Haotao ZengDepartment of Allergy, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China.
Lingzhi XuDepartment of Immunology, School of Basic Medical Sciences, Weifang Medical University, Weifang, China.
Jiangqi LiuDepartment of Allergy, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China.
Lihua MoState Key Laboratory of Respiratory Diseases Allergy Division, Shenzhen University and Institute of Allergy & Immunology of Shenzhen University, Room A7-509 at Lihu Campus of Shenzhen University. 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Minyao LiState Key Laboratory of Respiratory Diseases Allergy Division, Shenzhen University and Institute of Allergy & Immunology of Shenzhen University, Room A7-509 at Lihu Campus of Shenzhen University. 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Shuo SongState Key Laboratory of Respiratory Diseases Allergy Division, Shenzhen University and Institute of Allergy & Immunology of Shenzhen University, Room A7-509 at Lihu Campus of Shenzhen University. 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Xuejie XuState Key Laboratory of Respiratory Diseases Allergy Division, Shenzhen University and Institute of Allergy & Immunology of Shenzhen University, Room A7-509 at Lihu Campus of Shenzhen University. 1066 Xueyuan Blvd, Shenzhen, 518055, China.
Shihan MiaoShenzhen Senior High School Group, Shenzhen, China.
Miao ZhaoDepartment of Allergy, Longgang ENT Hospital & Shenzhen ENT Institute, Shenzhen, China. miaorzhao@mailnesia.com.
Pingchang YangState Key Laboratory of Respiratory Diseases Allergy Division, Shenzhen University and Institute of Allergy & Immunology of Shenzhen University, Room A7-509 at Lihu Campus of Shenzhen University. 1066 Xueyuan Blvd, Shenzhen, 518055, China. pcy2356@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cause of food allergy (FA) is still a mystery. Telomerases are involved in the regulation of immune responses. This study aims to gain an understanding of the contribution of telomerase reverse transcriptase (TERT) to the pathogenesis of FA.

methodsA murine FA model was established with ovalbumin as the specific antigen. The role of TERT in regulating dendritic cell (DC) immune tolerogenic functions was evaluated in this murine model.

resultsWe observed that the Tert promoter was at demethylation status and the Tert expression was elevated in DCs of FA mice. The Tert expression in DCs had a positive correlation with the FA response. TERT prevented the induction of Il10 expression in DCs. The immune tolerogenic functions of DCs were diminished by TERT. The immune tolerogenic functions of DC were restored by CpG by boosting the Tert promoter methylation. Administration of CpG promoted the therapeutic effects of allergen specific immunotherapy in FA mice.

conclusionsLow levels of Il10 expression and high levels of Tert expression were observed in intestinal DCs of FA mice. CpG exposure restored the expression of Il10 and increased the therapeutic benefits of allergen-specific immunotherapy.

Indexed as

Dendritic CellsDNA MethylationFood HypersensitivityInterleukin-10Promoter Regions, GeneticSignal TransductionTelomeraseAllergensAnimalsDesensitization, ImmunologicDisease Models, AnimalFemaleHumansImmune ToleranceMiceMice, Inbred BALB CAllergensIL10 protein, mouseInterleukin-10OvalbuminTelomeraseTert protein, mousedendritic cellFood allergyIL-10immunotherapyTERT

Identifiers

PMID39034374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.