Evidence map›Paper›PMID 39034149›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2024

[A multicenter clinical study on the incidence and influencing factors of cephalosporin-induced anaphylaxis].

Ping Yang, Dandan Dai, Qingyu Li, Haichao Zhan, Xumei Li, Xiaoyan Lu, Min He, Na Chen, Saiping Jiang, Xiaoyang Lu

Abstract readMulticenter StudyEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ping YangDepartment of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. tracystrawberry@zju.edu.cn.
Dandan DaiDepartment of Pharmacy, the First Affiliated Hospital of Ningbo University, Ningbo 315000, Zhejiang Province, China.
Qingyu LiDepartment of Clinical Pharmacy, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Haichao ZhanDepartment of Clinical Pharmacy, Jinhua Central Hospital, Jinhua 321000, Zhejiang Province, China.
Xumei LiDepartment of Clinical Pharmacy, the Second Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China.
Xiaoyan LuDepartment of Clinical Pharmacy, Ningbo Second Hospital, Ningbo 315010, Zhejiang Province, China.
Min HeDepartment of Clinical Pharmacy, Department of Clinical Pharmacy, Xiaoshan District First People's Hospital, Hangzhou 311200, China.
Na ChenDepartment of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Saiping JiangDepartment of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. j5145@zju.edu.cn.
Xiaoyang LuDepartment of Clinical Pharmacy, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. luxiaoyang@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the incidence and influencing factors of allergic reactions to cephalosporins.

methodsA cross-sectional study of 29 medical institutions in Zhejiang Province was conducted from April 2021 to June 2021. The incidence of allergic reactions to cephalosporins was investigated, and the influencing factors of cephalosporin-induced allergic reactions were analyzed by Poisson regression.

resultsA total of 56 155 patients were included in this study. The total incidence of allergic reactions to cephalosporin was 1.67‰, the highest incidence of anaphylaxis occurred for ceftizoxime (4.27‰), followed by ceftriaxone (3.49‰) and cefotaxime (2.40‰). There was no significant difference in the incidence of allergic reactions between patients with negative skin tests and those without skin tests (1.75‰

conclusionsLower BMI and history of β-lactam antibiotics allergy increase the risk of cephalosporin allergic reactions. The routine skin test may not reduce the occurrence of allergic reactions to cephalosporins.

Indexed as

AnaphylaxisAnti-Bacterial AgentsCephalosporinsDrug HypersensitivityAdultCefotaximeCeftizoximeCeftriaxoneCross-Sectional StudiesFemaleHumansIncidenceMaleMiddle AgedSkin TestsAnti-Bacterial AgentsCefotaximeCeftizoximeCeftriaxoneCephalosporinsAnaphylaxisBody mass indexCephalosporinSkin testβ-lactam antibiotics

Identifiers

PMID39034149
PMCPMC11528139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.