Evidence map›Paper›PMID 39034131›Full record

ArticlePhysiological reports2024

Alveolar hypoxia induces organ-specific inflammasome-related inflammation in male mouse lungs.

Camilla Udjus, Bente Halvorsen, Xiang Yi Kong, Ellen Lund Sagen, Marita Martinsen, Kuan Yang, Else Marit Løberg, Geir Christensen, Ole Henning Skjønsberg, Karl-Otto Larsen

Abstract read
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In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Camilla UdjusDepartment of Pulmonary Medicine, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway.ORCID 0000-0002-6401-7341
Bente HalvorsenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Xiang Yi KongResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.
Ellen Lund SagenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Marita MartinsenInstitute for Experimental Medical Research, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway.
Kuan YangResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.
Else Marit LøbergDepartment of Pathology, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway.
Geir ChristensenInstitute for Experimental Medical Research, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway.
Ole Henning SkjønsbergDepartment of Pulmonary Medicine, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway.
Karl-Otto LarsenDepartment of Pulmonary Medicine, Oslo University Hospital Ullevål and University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation through activation of caspase-1, seems to play a role in pulmonary hypertension induced by alveolar hypoxia. Whether alveolar hypoxia induces caspase-1-mediated inflammation and influx of leukocytes in other organs than the lungs, is not known. Our aim was to explore sites of caspase-1-related inflammation in alveolar hypoxia. Wild type (WT) mice were exposed to environmental hypoxia or room-air, and organs were analyzed. Right heart catheterization was performed after 14 days of alveolar hypoxia in WT mice and mice transplanted with WT or caspase-1

Indexed as

Caspase 1HypoxiaInflammasomesInterleukin-18LungMice, Inbred C57BLAnimalsHypertension, PulmonaryInflammationMaleMiceMice, KnockoutPulmonary AlveoliSTAT3 Transcription FactorCasp1 protein, mouseCaspase 1InflammasomesInterleukin-18STAT3 Transcription FactorCaspase‐1hypoxiaIL‐18inflammationpulmonary hypertension

Identifiers

PMID39034131
PMCPMC11260499

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.