Evidence map›Paper›PMID 39033477›Full record

ArticleCell biochemistry and biophysics2024

Effect of Xanthohumol from Humulus lupulus L. Against Gouty Bone Damage in Arthritis of Rats Induced by Mono-sodium Urate.

Jianyong Han, Tianshuang Xia, Yiping Jiang, Weiqing Fan, Nani Wang, Yue Zhang, Aijun Liu, Kai Zhao, Hailiang Xin

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Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianyong Han *School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Tianshuang Xia *School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Yiping JiangSchool of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Weiqing FanYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200433, China.
Nani WangDepartment of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, 310007, China.
Yue ZhangSchool of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Aijun LiuSchool of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Kai ZhaoHebei Kingsci Pharmaceutical Technology, Shijiazhuang, 050035, China.
Hailiang XinSchool of Pharmacy, Naval Medical University, Shanghai, 200433, China. hailiangxin@163.com.

Funding

National Natural Science Foundation of China 82174079Project of Science and Technology Commission of Shanghai Municipality 21S21902600
6 · The paper itself

Abstract

Xanthohumol (XAN) is an isoprenyl flavonoid from Humulus lupulus L. known for beer brewing, and an osteoprotective agent due to its active improvement in bone loss of osteoporosis. This study was first time to investigate its effects on anti-gouty bone injury in rats of gouty arthritis (GA) induced by monosodium urate (MSU). Results showed that XAN could significantly exert anti-inflammatory activity by alleviating swelling degree of joints, reducing serum level of inflammatory factors, improving inflammatory injury and degrading the Markin's score in lesion joint. Meanwhile, XAN could also fight against gouty bone damage by improving pathological changes of bone tissue and parameters of bone micro-structure. Moreover, XAN could even promote bone formation by effectively enhancing expression of Runx2 and OPG, while inhibit bone resorption with depressing matrix metalloproteinase-9 (MMP-9), MMP-13 and CTSK expression, reducing RANKL secretion, and abating the ratio of RANKL/OPG. Therefore, it was the first time to reveal the mechanism of XAN against gouty bone injury via inhibiting RANKL/OPG/RANK signaling pathway. Above all, this study provided potential strategy for the treatment of GA, and further contributed to research and resource development for hops.

Indexed as

Arthritis, GoutyFlavonoidsHumulusPropiophenonesUric AcidAnimalsAnti-Inflammatory AgentsBone and BonesCore Binding Factor Alpha 1 SubunitMaleMatrix Metalloproteinase 9OsteogenesisOsteoprotegerinRANK LigandRatsRats, Sprague-DawleyAnti-Inflammatory AgentsCore Binding Factor Alpha 1 SubunitFlavonoidsMatrix Metalloproteinase 9OsteoprotegerinPropiophenonesRANK LigandRunx2 protein, ratUric AcidxanthohumolGouty arthritisGouty bone damageHumulus lupulus L.Monosodium urateXanthohumol

Identifiers

PMID39033477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.