Evidence map›Paper›PMID 39033175›Full record

ArticleNature communications2024

The structural insight into the functional modulation of human anion exchanger 3.

Liyan Jian, Qing Zhang, Deqiang Yao, Qian Wang, Moxin Chen, Ying Xia, Shaobai Li, Yafeng Shen, Mi Cao, An Qin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liyan Jian *Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-4521-817X
Qing Zhang *Institute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.
Deqiang Yao *Institute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.ORCID 0000-0003-4881-265X
Qian WangInstitute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.
Moxin ChenDepartment of Ophthalmology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ying XiaInstitute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.
Shaobai LiInstitute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.
Yafeng ShenInstitute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.
Mi CaoInstitute of Precision Medicine, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 115 Jinzun Road, Shanghai, China.
An QinDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. dr_qinan@163.com.ORCID 0000-0002-8785-8848
Lin LiDepartment of Ophthalmology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. lin_li@sjtu.edu.cn.
Yu CaoDepartment of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yu.cao@shsmu.edu.cn.ORCID 0000-0003-1409-2068

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2018YFC1004704National Natural Science Foundation of China (National Science Foundation of China) 82072468National Natural Science Foundation of China (National Science Foundation of China) 82272519National Natural Science Foundation of China (National Science Foundation of China) 82371067National Natural Science Foundation of China (National Science Foundation of China) 82372430National Natural Science Foundation of China (National Science Foundation of China) 92068102NCI NIH HHS P30 CA008748Shanghai Municipal Education Commission SHSMU-ZLCX20211700
6 · The paper itself

Abstract

Anion exchanger 3 (AE3) is pivotal in regulating intracellular pH across excitable tissues, yet its structural intricacies and functional dynamics remain underexplored compared to other anion exchangers. This study unveils the structural insights into human AE3, including the cryo-electron microscopy structures for AE3 transmembrane domains (TMD) and a chimera combining AE3 N-terminal domain (NTD) with AE2 TMD (hAE3

Indexed as

Antiporters4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidBinding SitesCryoelectron MicroscopyHEK293 CellsHumansHydrogen-Ion ConcentrationModels, MolecularProtein ConformationProtein Domains4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAntiportersSLC4A3 protein, human

Identifiers

PMID39033175
PMCPMC11271275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.