Evidence map›Paper›PMID 39033030›Full record

ReviewOccupational and environmental medicine2024

Critical reviews of exposure assessment in carcinogenic hazard identification: the IARC

Daniel R S Middleton, Roland Wedekind, Amy L Hall, Eero Suonio, Nathan DeBono, Roel Vermeulen, Lin Fritschi, Patricia A Stewart, Mary K Schubauer-Berigan

Abstract readReview
In one paragraph

Review in Occupational and environmental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel R S Middleton *International Agency for Research on Cancer, Lyon, France.
Roland Wedekind *International Agency for Research on Cancer, Lyon, France wedekindr@iarc.who.int.ORCID 0000-0003-1364-7666
Amy L HallVeterans Affairs Canada, Charlottetown, Prince Edward Island, Canada.ORCID 0000-0003-1502-2694
Eero SuonioInternational Agency for Research on Cancer, Lyon, France.
Nathan DeBonoInternational Agency for Research on Cancer, Lyon, France.
Roel VermeulenIRAS, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-4082-8163
Lin FritschiSchool of Public Health, Curtin University, Perth, Western Australia, Australia.ORCID 0000-0002-7692-3560
Patricia A StewartStewart Exposure Assessments, Arlington, Virginia, USA.
Mary K Schubauer-BeriganInternational Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-5175-924X

Funding

IARC Monographs on the Identification of Carcinogenic Hazards to HumansR01CA033193 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI SCHUBAUER-BERIGAN, MARY K. · 2021 to 2025
$4.9M
NCI NIH HHS R01 CA033193World Health Organization 001
6 · The paper itself

Abstract

objectivesTo summarise the rationale, workflow and recommendations for the conduct of exposure assessment critiques in key human studies evaluated for International Agency for Research on Cancer (IARC)

methodsApproaches to evaluating exposure assessment quality in human cancer and mechanistic studies were reviewed according to the precepts outlined in the IARC

resultsThe case studies of night shift work (volume 124) and 1,1,1-trichloroethane (volume 130) used a common approach, tailored to the agents' specific exposure scenarios, to evaluate exposure assessment quality. Based on the experiences of IARC Working Groups to date, the implementation of exposure assessment critique requires the need for agent-specific knowledge, consideration of the validity of time-varying exposure metrics related to duration and intensity, and transparent, concise reviews that prioritise the most important strengths and limitations of exposure assessment methods used in human studies.

conclusionsExposure assessment has not historically been a fully appreciated component for evaluating the quality of epidemiological studies in cancer hazard identification. Exposure assessment critique in key human cancer and mechanistic studies is now an integral part of IARC

Indexed as

CarcinogensOccupational ExposureShift Work ScheduleHumansInternational AgenciesNeoplasmsRisk AssessmentCarcinogensEnvironmental ExposureEpidemiologyOccupational HealthToxicology

Identifiers

PMID39033030
PMCPMC11638842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.