Evidence map›Paper›PMID 39033027›Full record

ArticleThorax2024

Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes.

Christina M Eckhardt, Pallavi Balte, Jack E Morris, Surya P Bhatt, David Couper, Jessica Fetterman, Neal Freedman, David R Jacobs, Lifang Hou, Ravi Kalhan and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christina M EckhardtMedicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-3249-926X
Pallavi BalteColumbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Jack E MorrisColumbia University Mailman School of Public Health, New York, New York, USA.
Surya P BhattPulmonary, Allergy and Critical Care Medicine, University of Alabama School of Natural Sciences and Mathematics, Birmingham, Alabama, USA.ORCID 0000-0002-8418-4497
David CouperBiostatistics, The University of North Carolina, Chapel Hill, North Carolina, USA.
Jessica FettermanBoston University, Boston, Massachusetts, USA.
Neal FreedmanNutritional Epidemiology, National Institutes of Health, Bethesda, Maryland, USA.
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Lifang HouRobert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ravi KalhanNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Yongmei LiuDuke University, Durham, North Carolina, USA.
Laura LoehrThe University of North Carolina, Chapel Hill, North Carolina, USA.
Pamela L LutseyUniversity of Minnesota School of Public Health, Minneapolis, Minnesota, USA.ORCID 0000-0002-1572-1340
Joseph E SchwartzCenter for Behavioral Cardiovascular Health, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Wendy WhiteTougaloo College, Tougaloo, Mississippi, USA.
Sachin YendeUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6596-8034
Stephanie J LondonNIEHS, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-4911-5290
Tiffany R SanchezEnvironmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
Elizabeth C OelsnerMedicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA eco7@cumc.columbia.edu.

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of SmokersP01CA138338 · NCI · UNIVERSITY OF MINNESOTA · PI Sungshim Lani Park · 2010 to 2026
$33.4M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
STRONG HEART STUDY (SHS): OUHSC COORDINATING CENTER - TASK AREA B (B.1 AND B.3)75N92019D00027 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, YING · 2019 to 2025
$15.5M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
NCATS NIH HHS TL1 TR001875NCATS NIH HHS UL1 TR001873NCI NIH HHS P01 CA138338NHLBI NIH HHS 75N92019D00027NHLBI NIH HHS 75N92019D00028NHLBI NIH HHS 75N92019D00029NHLBI NIH HHS 75N92019D00030NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS K23 HL130627NHLBI NIH HHS K24 HL159246NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS R01 HL122477NHLBI NIH HHS R01 HL131136NHLBI NIH HHS R01 HL155576NHLBI NIH HHS R01 HL155691NHLBI NIH HHS R21 HL121457NHLBI NIH HHS R21 HL129924NHLBI NIH HHS R21 HL153700NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIAMS NIH HHS R01 AR073178NIA NIH HHS R01 AG081244NIA NIH HHS R21 AG068955NINDS NIH HHS R01 NS087541
6 · The paper itself

Abstract

introductionCigarette smoking leads to altered DNA methylation at the aryl-hydrocarbon receptor repressor (AHRR) gene. However, it remains unknown whether pipe or cigar smoking is associated with AHRR methylation. We evaluated associations of non-cigarette tobacco use with AHRR methylation and determined if AHRR methylation was associated with smoking-related health outcomes.

methodsData were pooled across four population-based cohorts that enrolled participants from 1985 to 2002. Tobacco exposures were evaluated using smoking questionnaires. AHRR cg05575921 methylation was measured in peripheral blood leucocyte DNA. Spirometry and respiratory symptoms were evaluated at the time of methylation measurements and in subsequent visits. Vital status was monitored using the National Death Index.

resultsAmong 8252 adults (mean age 56.7±10.3 years, 58.1% women, 40.6% black), 4857 (58.9%) participants used cigarettes and 634 (7.7%) used non-cigarette tobacco products. Exclusive use of non-cigarette tobacco products was independently associated with lower AHRR methylation (-2.44 units, 95% CI -4.42 to -0.45), though to a lesser extent than exclusive use of cigarettes (-6.01 units, 95% CI -6.01 to -4.10). Among participants who exclusively used non-cigarette tobacco products, reduced AHRR methylation was associated with increased respiratory symptom burden (OR 1.60, 95% CI 1.03 to 2.68) and higher all-cause mortality (log-rank p=0.02).

conclusionPipe and cigar smoking were independently associated with lower AHRR methylation in a multiethnic cohort of US adults. Among users of non-cigarette tobacco products, lower AHRR methylation was associated with poor respiratory health outcomes and increased mortality. AHRR methylation may identify non-cigarette tobacco users with an increased risk of adverse smoking-related health outcomes.

Indexed as

Basic Helix-Loop-Helix ProteinsDNA MethylationRepressor ProteinsTobacco ProductsAdultAgedFemaleHumansMaleMiddle AgedSmokingUnited StatesAHRR protein, humanBasic Helix-Loop-Helix ProteinsRepressor ProteinsClinical EpidemiologySmoking

Identifiers

PMID39033027
PMCPMC11483209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.