Evidence map›Paper›PMID 39032543›Full record

ArticleBrain, behavior, and immunity2024

Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation.

Richard J Maddock, Roza M Vlasova, Shuai Chen, Ana-Maria Iosif, Jeffrey Bennett, Costin Tanase, Amy M Ryan, Takeshi Murai, Casey E Hogrefe, Cynthia D Schumann and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Richard J MaddockDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address: rjmaddock@ucdavis.edu.
Roza M VlasovaDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
Shuai ChenDivision of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Ana-Maria IosifDivision of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Jeffrey BennettDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Costin TanaseDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Amy M RyanDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Takeshi MuraiDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Casey E HogrefeCalifornia National Primate Research Center, University of California Davis, Davis, CA, USA.
Cynthia D SchumannDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Daniel H GeschwindNeurogenetics Program, Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
Judy Van de WaterRheumatology/Allergy and Clinical Immunology, School of Medicine, University of California Davis, Sacramento, CA, USA; MIND Institute, School of Medicine, University of California Davis, Sacramento, CA, USA.
David G AmaralMIND Institute, School of Medicine, University of California Davis, Sacramento, CA, USA.
Tyler A LeshDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA.
Martin A StynerDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA.
A Kimberley McAllisterCenter for Neuroscience, University of California Davis, Davis, CA, USA.
Cameron S CarterDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address: cscarte1@hs.uci.edu.
Melissa D BaumanCalifornia National Primate Research Center, University of California Davis, Davis, CA, USA; MIND Institute, School of Medicine, University of California Davis, Sacramento, CA, USA; Physiology and Membrane Biology, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address: mdbauman@ucdavis.edu.

Funding

ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI FUJII, GARY · 1985 to 2011
$126.2M
UC Davis Conte Center: Neuroimmune Mechanisms of Psychiatric DisordersP50MH106438 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CARTER, CAMERON S. · 2015 to 2025
$26.1M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
NCRR NIH HHS P51 RR000169NICHD NIH HHS P50 HD103526NIMH NIH HHS P50 MH106438NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

Converging data show that exposure to maternal immune activation (MIA) in utero alters brain development in animals and increases the risk of neurodevelopmental disorders in humans. A recently developed non-human primate MIA model affords opportunities for studies with uniquely strong translational relevance to human neurodevelopment. The current longitudinal study used 1H-MRS to investigate the developmental trajectory of prefrontal cortex metabolites in male rhesus monkey offspring of dams (n = 14) exposed to a modified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimester. Brain metabolites in these animals were compared to offspring of dams that received saline (n = 10) or no injection (n = 4). N-acetylaspartate (NAA), glutamate, creatine, choline, myo-inositol, taurine, and glutathione were estimated from PRESS and MEGA-PRESS acquisitions obtained at 6, 12, 24, 36, and 45 months of age. Prior investigations of this cohort reported reduced frontal cortical gray and white matter and subtle cognitive impairments in MIA offspring. We hypothesized that the MIA-induced neurodevelopmental changes would extend to abnormal brain metabolite levels, which would be associated with the observed cognitive impairments. Prefrontal NAA was significantly higher in the MIA offspring across all ages (p < 0.001) and was associated with better performance on the two cognitive measures most sensitive to impairment in the MIA animals (both p < 0.05). Myo-inositol was significantly lower across all ages in MIA offspring but was not associated with cognitive performance. Taurine was elevated in MIA offspring at 36 and 45 months. Glutathione did not differ between groups. MIA exposure in male non-human primates is associated with altered prefrontal cortex metabolites during childhood and adolescence. A positive association between elevated NAA and cognitive performance suggests the hypothesis that elevated NAA throughout these developmental stages reflects a protective or resilience-related process in MIA-exposed offspring. The potential relevance of these findings to human neurodevelopmental disorders is discussed.

Indexed as

BrainMacaca mulattaPoly I-CPrefrontal CortexPrenatal Exposure Delayed EffectsAnimalsAspartic AcidCholineCreatineDisease Models, AnimalFemaleGlutamic AcidGlutathioneInositolLongitudinal StudiesMaleAspartic AcidCholineCreatineGlutamic AcidGlutathioneInositolN-acetylaspartatePoly I-CTaurineAdolescenceChildhoodGestational immune activationMacaqueMagnetic resonance spectroscopyMyo-inositolN-acetylaspartatePrefrontalResilience

Identifiers

PMID39032543
PMCPMC11809764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.