Evidence map›Paper›PMID 39032482›Full record

ReviewCurrent opinion in cell biology2024

Post-transcriptional regulation as a conserved driver of neural crest and cancer-cell migration.

Arvind Arul Nambi Rajan, Erica J Hutchins

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Arvind Arul Nambi RajanDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Erica J HutchinsDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA. Electronic address: erica.hutchins@ucsf.edu.

Funding

Mechanisms of RNA turnover during the epithelial-mesenchymal transitionR35GM150763 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Erica Hutchins · 2023 to 2026
$1.6M
Characterization of the roles and regulation of Draxin in cranial neural crestR00DE028592 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUTCHINS, ERICA · 2022 to 2024
$1.1M
NIDCR NIH HHS R00 DE028592NIGMS NIH HHS R35 GM150763
6 · The paper itself

Abstract

Cells have evolved mechanisms to migrate for diverse biological functions. A process frequently deployed during metazoan cell migration is the epithelial-mesenchymal transition (EMT). During EMT, adherent epithelial cells undergo coordinated cellular transitions to mesenchymalize and reduce their intercellular attachments. This is achieved via tightly regulated changes in gene expression, which modulates cell-cell and cell-matrix adhesion to allow movement. The acquisition of motility and invasive properties following EMT allows some mesenchymal cells to migrate through complex environments to form tissues during embryogenesis; however, these processes may also be leveraged by cancer cells, which often co-opt these endogenous programs to metastasize. Post-transcriptional regulation is now emerging as a major conserved mechanism by which cells modulate EMT and migration, which we discuss here in the context of vertebrate development and cancer.

Indexed as

Cell MovementEpithelial-Mesenchymal TransitionNeoplasmsNeural CrestAnimalsHumansRNA Processing, Post-Transcriptional

Identifiers

PMID39032482
PMCPMC11346372

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.