Evidence map›Paper›PMID 39032117›Full record

ArticleEuropean eating disorders review : the journal of the Eating Disorders Association2025

Circadian copeptin and oxytocin profiles in anorexia nervosa: Exploring the interplay with neurohypophysis opioid tone.

Sandra Doua, Natacha Germain, Manel Merabet, Jérôme Redouté, Claire Boutet, Fabien Schneider, Amira Hammour, Aurélia Gay, Catherine Massoubre, Bruno Estour and 1 more

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Article in European eating disorders review : the journal of the Eating Disorders Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Circadian copeptin and oxytocin profiles in anorexia nervosa: Exploring the interplay with neurohypophysis opioid tone.European eating disorders review : the journal of the Eating Disorders Association · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sandra DouaTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Natacha GermainTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.ORCID 0000-0001-6949-7244
Manel MerabetTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Jérôme RedoutéCERMEP-imaging Platform, Lyon, France.
Claire BoutetTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Fabien SchneiderTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Amira HammourTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Aurélia GayTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Catherine MassoubreTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Bruno EstourTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.
Bogdan GaluscaTAPE Research Group, Jean Monnet University, Lyon University, Saint-Etienne, France.ORCID 0000-0002-0154-6924

Funding

Programme Hospitalier de Recherche Clinique Grant PHRC Interregional no. 0908019, French Ministry of Health
6 · The paper itself

Abstract

contextNeurohypophysis (NH) function in eating disorders (ED) remains poorly elucidated. Studies on vasopressin and oxytocin display inconclusive findings regarding their levels and associations with psychological complications in ED. The profile of opioid tone, a crucial NH activity regulator, is also unknown.

objectiveTo characterise the circadian profile of NH hormones and NH opioid tone using positron emission tomography/MRI (PET/MRI) imaging in patients with ED compared to healthy controls.

methodsTwelve-point plasma circadian profiles of copeptin and oxytocin, alongside nutritional and psychological scores, were assessed in age-matched female participants: 13 patients with anorexia nervosa restrictive-type (ANR), 12 patients recovered from AN (ANrec), 14 patients with bulimia nervosa and 12 controls. Neurohypophysis PET/MRI [

resultsResults revealed lower copeptin circadian levels in both ANR and ANrec compared to controls, with no oxytocin differences. Bulimia nervosa exhibited elevated copeptin and low oxytocin levels. [

conclusionCopeptin demonstrated significant group differences, highlighting its potential diagnostic and prognostic value. Oxytocin levels exhibited conflicting results, questioning the reliability of peripheral blood assessment. Increased NH opioid tone in anorexia nervosa may influence the vasopressin or oxytocin release, suggesting potential therapeutic applications.

Indexed as

Anorexia NervosaCircadian RhythmGlycopeptidesOxytocinAdolescentAdultFemaleHumansMagnetic Resonance ImagingPituitary Gland, PosteriorPositron-Emission TomographyYoung AdultcopeptinsGlycopeptidesOxytocinanorexia nervosabiologicalbulimia nervosaneuroimaging

Identifiers

PMID39032117
PMCPMC11617818

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.