ArticleJournal of periodontology2025
Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature-induced periodontitis in mice.
Article in Journal of periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Evaluation of gossypetin's effects on gut microbiota profile and TLR4, Myd88, NFKB, and NLRP3 signaling pathways in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Aglycone, Glycoside, or Glucuronide? Experimental and Mechanistic Insights into the Antioxidative Potential of Gossypetin, Gossypin, and Hibifolin.The journal of physical chemistry. B · 2025Article
- Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature-induced periodontitis in mice.Journal of periodontology · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundBacterial-induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.
methodsIn the present study, we demonstrated an inhibitory effect of gossypetin, a hexahydroxy flavone, on osteoclast differentiation and bone resorption using in vitro culture of osteoclasts from mouse bone marrow macrophage (BMM) precursors and in vivo model of ligature-induced periodontitis in mice.
resultsGossypetin significantly reduced the differentiation of osteoclasts from mouse BMM precursors in the presence of the receptor activator of nuclear factor κB ligand (RANKL). In vitro, gossypetin inhibited critical signaling events downstream of RANKL including the auto-amplification of nuclear factor of activated T-cells, cytoplasmic 1, Ca
conclusionTaken together, these results show anti-osteoclastogenic and anti-inflammatory effects of gossypetin, suggesting the potential use of this natural compound in periodontitis.
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