Evidence map›Paper›PMID 39031618›Full record

ArticlePhysiological reports2024

Stimulation of the calcium-sensing receptor induces relaxations through CGRP and NK1 receptor-mediated pathways in male rat mesenteric arteries.

Simonette R E Carlton-Carew, Harry Z E Greenberg, Iain A Greenwood, Anthony P Albert

Abstract read
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  2. Role of the calcium-sensing receptor in regulating vascular function.Journal of cell communication and signaling · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simonette R E Carlton-CarewVascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK.
Harry Z E GreenbergVascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK.
Iain A GreenwoodVascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK.
Anthony P AlbertVascular Biology Section, Cardiovascular & Genomics Research Institute, St. George's, University of London, London, UK.ORCID 0000-0002-3596-9634

Funding

British Heart Foundation (BHF) FS/13/10/30021British Heart Foundation (BHF) FS/17/40/32942UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/J007226/1
6 · The paper itself

Abstract

Stimulation of the calcium-sensing receptor (CaSR) regulates vascular contractility, but cellular mechanisms involved remain unclear. This study investigated the role of perivascular sensory nerves in CaSR-induced relaxations of male rat mesenteric arteries. In fluorescence studies, colocalisation between synaptophysin, a synaptic vesicle marker, and the CaSR was present in the adventitial layer of arterial segments. Using wire myography, increasing external Ca

Indexed as

Calcitonin Gene-Related PeptideMesenteric ArteriesReceptors, Calcium-SensingReceptors, Neurokinin-1VasodilationAnimalsCalcitonin Gene-Related Peptide Receptor AntagonistsCalciumCapsaicinMaleNeurokinin-1 Receptor AntagonistsRatsRats, WistarSignal TransductionCalcitonin Gene-Related PeptideCalcitonin Gene-Related Peptide Receptor AntagonistsCalciumCapsaicinNeurokinin-1 Receptor AntagonistsReceptors, Calcium-SensingReceptors, Neurokinin-1calcitonin gene‐related peptidecalcium‐sensing receptorperivascular sensory nervessubstance Pvascular smooth muscle

Identifiers

PMID39031618
PMCPMC11189779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.