Evidence map›Paper›PMID 39031565›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Allicin‒Decorated FeO

Zhongming Jie, Bingyan Xiong, Jianlin Shi

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Allicin‒Decorated FeOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zhongming JieShanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.
Bingyan XiongShanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.ORCID 0000-0001-7682-9956
Jianlin ShiShanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai, 200072, P. R. China.ORCID 0000-0001-8790-195X

Funding

Basic Research Program of Shanghai Municipal Government 21JC1406000CAMS Innovation Fund for Medical Sciences 2021‒I2M‒5‒012Fundamental Research Funds for the Central Universities 22120220209Key Research Program of Frontier Sciences, Chinese Academy of Sciences ZDBS‒LY‒SLH029National Key Research and Development Program of China 2022YFB3804500National Natural Science Foundation of China 22335006National Natural Science Foundation of China 52201271Shanghai Municipal Health Commission 20234Y0114
6 · The paper itself

Abstract

In the tumor treatment by Fenton reaction‒based nanocatalytic medicines, the gradual consumption of Fe(II) ions greatly reduces the production of hydroxyl radicals, one of the most active reactive oxygen species (ROS), leading to much deteriorated therapeutic efficacy. Meanwhile, the ROS consumption caused by the highly expressed reduced glutathione (GSH) in the tumor microenvironment further prevents tumor apoptosis. Therefore, using the highly expressed GSH in tumor tissue to promote the Fe(III) reduction to Fe(II) can not only weaken the resistance of tumor to ROS attack, but also generate enough Fe(II) to accelerate the Fenton reaction. In view of this, an allicin‒modified FeO

Indexed as

DisulfidesSulfinic AcidsAnimalsCatalysisCell Line, TumorDisease Models, AnimalGlutathioneHumansIronMiceNanomedicineNeoplasmsReactive Oxygen SpeciesTumor MicroenvironmentallicinDisulfidesGlutathioneIronReactive Oxygen SpeciesSulfinic AcidsallicinFe(II, III) cyclingFenton reactionGSH oxidationtumor therapy

Identifiers

PMID39031565
PMCPMC11348051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.