ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
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Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- Proof-of-concept study: APOE4 brain endothelial cells as a phenotypic compound screen.Alzheimer's research & therapy · 2026Article
- Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting Microglial Phagocytosis for Alzheimer's Disease Management: Natural, Pharmacological, Nanoparticle, and Gene Therapy Approaches.CNS & neurological disorders drug targets · 2026Review
- Human iPSC-derived APOE4/4 Alzheimer´s disease astrocytes exhibit a senescent and pro-inflammatory state that compromises neuronal support.Journal of neuroinflammation · 2025Article
- Associations of alcohol drinking with incident dementia: a prospective study from the UK Biobank.European journal of epidemiology · 2025Observational
- Review
- Advances of therapeutic strategies for Alzheimer's disease.Journal of neurology · 2025Review
- Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy.The FEBS journal · 2025Review
- Microglia Single-Cell RNA-Seq Enables Robust and Applicable Markers of Biological Aging.Aging cell · 2025Article
- Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts.Annals of neurology · 2025Article
- New Approaches to the Treatment of Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The relationship between the APOE genotypes and memory performance of young adults and its neural basis.Scientific reports · 2025Article
- Focused ultrasound-mediated APOE4 knockdown in mouse brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC.Molecular cancer · 2025Article
- Article
- APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy.Acta pharmaceutica Sinica. B · 2025Article
- The impact of APOE4 on neurological symptoms after exposure to K. brevis neurotoxin.Environmental toxicology and pharmacology · 2025Article
- Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging Clocks.bioRxiv : the preprint server for biology · 2024Article
- Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
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Authors and funding
60 authors.
Courtney M KloskeAlzheimer's Association, Chicago, Illinois, USA.
Michael E BelloyDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, Palo Alto, California, USA.
Elizabeth E BlueDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, USA.
Gregory R BowmanDepartments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maria C CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Xiaoying ChenDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Ornit Chiba-FalekDivision of Translational Brain Sciences, Department of Neurology, Duke University School of Medicine, Durham, North Carolina, USA.
Albert A DavisDepartment of Neurology Hope Center for Neurological Disorders Washington University School of Medicine, St. Louis, Missouri, USA.
Gilbert Di PaoloDenali Therapeutics Inc., San Francisco, California, USA.
Francesca GarrettiRonald M. Loeb Center for Alzheimer's Disease, New York, New York, USA.
David GateThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Lesley R GoldenDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Jay W HeineckeDepartment of Medicine, University of Washington, UV Medicine, Seattle, Washington, USA.
Joachim HerzCenter for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Yadong HuangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, California, USA.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
Lance A JohnsonDepartment of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Takahisa KanekiyoDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
Celeste M KarchDepartment of Psychiatry, Washington University in St Louis, St. Louis, Missouri, USA.
Anastasia KhvorovaRNA Therapeutic Institute, UMass Chan Medical School, Worcester, Massachusetts, USA.
Sascha J Koppes-den HertogDepartment of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.
Bruce T LambStark Neurosciences Research Institute Indiana University School of Medicine, Indianapolis, Indiana, USA.
Paige E LawlerDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA.
Yann Le GuenDepartment of Neurology and Neurological Sciences, Stanford University, Palo Alto, California, USA.
Alexandra LitvinchukDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Chia-Chen LiuDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
Simin MahinradAlzheimer's Association, Chicago, Illinois, USA.
Edoardo MarcoraDepartment of Genetics and Genomic Sciences, Nash Family Department of Neuroscience, Icahn Genomics Institute; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Claudia MarinoSchepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA.
Danny M MichaelsonSagol School of Neuroscience Tel Aviv University, Tel Aviv, Israel.
Justin J MillerDepartments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Josh M MorgantiSanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA.
Priyanka S NarayanGenetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, Center for Alzheimer's and Related Dementias (CARD), National Institutes of Health, Maryland, USA.
Michel S NaslavskyHuman Genome and Stem-cell Research Center, Biosciences Institute, University of São Paulo, Rua do Matao, São Paulo, Brazil.
Marlies OosthoekNeurochemistry Laboratory, Department of Laboratory Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Kapil V RamachandranTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Abhirami RamakrishnanThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ana-Caroline RaulinMayo Clinic Florida, Jacksonville, Florida, USA.
Aiko RobertDepartment of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.
Rasha N M SalehNorwich Medical School, University of East Anglia, UK Clinical and Chemical Pathology, Norfolk, UK.
Claire SextonAlzheimer's Association, Chicago, Illinois, USA.
Nilomi ShahLexeo Therapeutics, New York, New York, USA.
Francis ShueMayo Clinic Florida, Jacksonville, Florida, USA.
Isabel J SibleUniversity of Southern California, Los Angeles, California, USA.
Andrea SorannoWashington University in Saint Louis, St. Louis, Missouri, USA, St. Louis, Missouri, USA.
Michael R StricklandDepartment of Neurology, Washington University School of Medicine, St. Louis, Missouri, St. Louis, Missouri, USA.
Julia TcwDepartment of Pharmacology, Physiology & Biophysics, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts, USA.
Manon ThierryCenter for Cognitive Neurology, Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
Li-Huei TsaiPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ryan A TuckeyDepartment of Neurology, Center for Neurodegeneration and Experimental Therapeutics, Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jason D UlrichDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Rik van der KantDepartment of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, USA.
Na WangMayo Clinic Rochester, Rochester, Minnesota, USA.
Cheryl L WellingtonDjavad Mowafaghian Centre for Brain Health Department of Pathology and Laboratory Medicine International Collaboration on Repair Discoveries School of Biomedical Engineering University of British Columbia, Vancouver, Canada.
Stacie C WeningerFBRI, Massachusetts, USA.
Hussein N YassineDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Na ZhaoDepartment of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
Guojun BuDivision of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
Alison M GoateDepartment of Genetics & Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, USA.
Funding
The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6MStructural Biology CoreU54AG065181 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Bruce T Lamb, Alan D. Palkowitz · 2019 to 2026
$61.3MProject 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI ALISON M GOATE · 2021 to 2026
$42.0MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0MResearch Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8MVISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5MUniversity of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5MProject 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omicsP01AG073082 · NIA · J. DAVID GLADSTONE INSTITUTES · PI HUANG, YADONG, MUCKE, LENNART · 2021 to 2025
$23.4MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MUtilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J · 2019 to 2023
$14.5MTransgenic/Behavior CoreP01AG060882 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAO, YONGZHAO · 2020 to 2024
$12.0MAlzheimer's Association 23AARG-1026607Alzheimer's Association AARF-20-683984Alzheimer's Association FAPESP13/08028-1Alzheimer's Drug Discovery Foundation GC-201711-2014197Biology and pathobiology of apoE in aging and Alzheimer's Disease GM131839-03Biology and pathobiology of apoE in aging and Alzheimer's Disease U54AG054345BrightFocus Foundation A2017458SBrightFocus Foundation A2021015FBrightFocus Foundation A2022010FCNPq 304746/2022-3Cure Alzheimer Fund and BrightFocus FoundationCure Alzheimer's FundDepartment of Defense W81XWH-21-1-0093Edward N. and Della L. Thome Memorial FoundationEichenbaum FoundationFidelity Biomedical Research InitiativeGood Ventures and Open PhilanthropyJPB FoundationKenneth and Bette Volk Endowed Chair of NeurologyMarie Skłodowska-Curie Actions 890650Massachusetts General Hospital Executive Committee (ECOR) on ResearchMedical Research Council (MRC, UK)MGH Research Scholar AwardMs. Lynne NaussNational Institute of General Medical Sciences (NIGMS) Center of Biomedical Research Excellence in CNS Metabolism P20GM148326National Institute on Aging (NIA) P30AG066530National Institute on Aging (NIA) R01AG054434National Institute on Aging (NIA) R01AG055770National Institute on Aging (NIA) R01AG060056National Institute on Aging (NIA) R01AG062550National Institute on Aging (NIA) R01AG067063National Institute on Aging (NIA) R01AG080589National Institute on Aging (NIA) R01AG081421National Institute on Aging (NIA) R21AG056518National Institute on Aging (NIA) RF1AG076124National Institute on Aging (NIA) RF1AG077627National Institute on Aging (NIA) RF1AG078362National Institute on Aging (NIA) U19NEI NIH HHS P30 EY003790NHLBI NIH HHS R01 HL149685NIA NIH HHS F32 AG082483NIA NIH HHS K01 AG062683NIA NIH HHS K24 AG053435NIA NIH HHS K99 AG075238NIA NIH HHS P01 AG060882NIA NIH HHS P01 AG073082NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072946NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG054671NIA NIH HHS R01 AG055770NIA NIH HHS R01 AG057522NIA NIH HHS R01 AG059737NIA NIH HHS R01 AG060056NIA NIH HHS R01 AG061186NIA NIH HHS R01 AG062550NIA NIH HHS R01 AG062837NIA NIH HHS R01 AG066395NIA NIH HHS R01 AG067063NIA NIH HHS R01 AG068395NIA NIH HHS R01 AG070830NIA NIH HHS R01 AG080589NIA NIH HHS R01 AG081228NIA NIH HHS R01 AG081421NIA NIH HHS R01 AG082362NIA NIH HHS R01 AG083941NIA NIH HHS R21 AG056518NIA NIH HHS R41 AG077992NIA NIH HHS R56 AG078733NIA NIH HHS RF1 AG046205NIA NIH HHS RF1 AG067194NIA NIH HHS RF1 AG074566NIA NIH HHS RF1 AG076124NIA NIH HHS RF1 AG077627NIA NIH HHS RF1 AG078362NIA NIH HHS RF1 AG083753NIA NIH HHS T32 AG058518NIA NIH HHS T32 AG078110NIA NIH HHS U01 AG058589NIA NIH HHS U01 AG058635NIA NIH HHS U19 AG069701NIA NIH HHS U54 AG054345NIA NIH HHS U54 AG065181NIGMS NIH HHS P20 GM148326NIGMS NIH HHS R35 GM131839NIGMS NIH HHS R35 GM152085NIGMS NIH HHS T32 GM008361NIH HHS 1U19AG069701NIH HHS 3RF1NS118558NIH HHS 5R01AG070830NIH HHS 7DP5OD028133NIH HHS DP5 OD019833NIH HHS DP5 OD028133NIH HHS F32AG08483NIH HHS K01AG062683NIH HHS K08NS101118NIH HHS K24AG053435NIH HHS K99AG075238NIH HHS P30EY003790NIH HHS R01 AG068395NIH HHS R01 AG081228NIH HHS R01AG082362NIH HHS R01AG083941NIH HHS R01AG66395NIH HHS R56AG078733NIH HHS R56AG081417NIH HHS RF1AG046205NIH HHS RF1AG067194NIH HHS RF1AG083753NIH HHS T32AG058518NIH HHS T32AG05851804NIH HHS T32 AG078110NIH HHS T32 GM008361NIH HHS U01AG058635NIH HHS U19AG069701NIH HHS U54NS110435NIH HHS W81XWH2010934NIH/NIA P01AG060882NIH/NIA P01AG073082NIH/NIA P30AG066512NIH/NIA R01AG059737NIH/NIA R01AG062837NIH/NIA U01AG058589NIH/NIA U19AG069701NIH-NIDDK Intramural Research ProgramNINDS NIH HHS K08 NS101118NINDS NIH HHS R01 NS104022NINDS NIH HHS R01 NS118558NINDS NIH HHS R01 NS126467NINDS NIH HHS RF1 NS110048NINDS NIH HHS RF1 NS118558NINDS NIH HHS T32 NS095775NINDS NIH HHS U54 NS110435NINDS NIH HHS UH3 NS100121NS126467 ApoE4, neurovascular injury and cognitive impairmentNSF GRFP Fellowship DGE-1745038NuBrain Consortium MR/T001852/1ODCDC CDC HHS DP5 OD019833Remondi Family FoundationRobert J. Kleberg, Jr. and Helen C. Kleberg FoundationTRIAD P01AG073082TRIAD R01AG061186TRIAD R01HL149685Vranos and Tiny Foundations
Abstract
introductionThe apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.
methodsIn 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.
resultsThis manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field. DISCUSSION: Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine. HIGHLIGHTS: APOE is a central player in the pathogenesis of Alzheimer's disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.
Indexed as
Alzheimer DiseaseApolipoproteins EAmyloid beta-PeptidesAnimalsBiomedical ResearchCongresses as TopicDementiaHumansAmyloid beta-PeptidesApolipoproteins EAlzheimer's diseaseAPOEapolipoprotein Econference proceedingsdementialipidsmicroglianeuroinflammationrisk factortherapeuticsvasculature
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