Evidence map›Paper›PMID 39031273›Full record

ArticleJournal of hematopathology2024

Paraneoplastic glomerulonephritis and kidney infiltration by mantle cell lymphoma: A diagnostic challenge.

Ana Lerma-Verdejo, Maribel Monroy-Condori, Xavier E Guerra-Torres, Nahir Daniela Moreno Paredes, Anastasio Serrano Egea, Francisco Díaz, Jorge L Morales-Montoya, Jacobo Galán Vega, Iván Arenas-Moncaleano, Fernando Solano Ramos

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In one paragraph

Article in Journal of hematopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Lerma-VerdejoDepartment of Hematology and Hemotherapy, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain. analermaverdejo@gmail.com.ORCID http://orcid.org/0000-0001-7181-6195
Maribel Monroy-CondoriDepartment of Nephrology, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Xavier E Guerra-TorresDepartment of Nephrology, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Nahir Daniela Moreno ParedesDepartment of Hematology and Hemotherapy, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Anastasio Serrano EgeaDepartment of Anatomic Pathology, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Francisco DíazDepartment of Anatomic Pathology, Hospital Gregorio Marañón, Madrid, Spain.
Jorge L Morales-MontoyaDepartment of Nephrology, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Jacobo Galán VegaDepartment of Hematology and Hemotherapy, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Iván Arenas-MoncaleanoDepartment of Nephrology, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.
Fernando Solano RamosDepartment of Hematology and Hemotherapy, Hospital General Universitario Nuestra Señora del Prado, Talavera de La Reina, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) is a rare and aggressive type of lymphoma that can affect the kidneys. The disease can lead to kidney impairment, and glomerulonephritis (GN) is a rare but serious complication of MCL. We report a case of MCL with kidney interstitial infiltration and membranoproliferative glomerulonephritis with focal and segmental glomerulosclerosis. A 75-year-old man presented recurrent acute kidney failure and worsening of nephrotic syndrome. Kidney biopsy revealed membranoproliferative glomerulonephritis presented immunoglobulin and complement deposition, focal and segmental glomerulosclerosis of not otherwise specified type, and infiltration by mantle cell lymphoma. Bone marrow biopsy and PET/CT scan confirmed the diagnosis of mantle cell lymphoma. The patient was treated with R-CHOP21 chemotherapy with cyclophosphamide dose adjustment for nephroprotection. He achieved complete remission with normalization of hematological parameters, improvement of kidney function, and reduction of proteinuria and albuminuria. This case shows the importance of considering alternative diagnoses in patients with recurrent chronic kidney disease and worsening nephrotic syndrome. Early diagnosis and treatment of mantle cell lymphoma can lead to favorable outcomes.

Indexed as

Lymphoma, Mantle-CellAgedAntineoplastic Combined Chemotherapy ProtocolsBiopsyCyclophosphamideDoxorubicinGlomerulonephritisGlomerulonephritis, MembranoproliferativeHumansKidneyMaleParaneoplastic SyndromesPrednisoneRituximabVincristineCyclophosphamideDoxorubicinPrednisoneR-CHOP protocolRituximabVincristineKidney infiltrationMantle cell lymphomaMembranoproliferative glomerulonephritisNephrotic syndrome

Identifiers

PMID39031273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.