Evidence map›Paper›PMID 39031214›Full record

Observational studyJournal of cancer research and clinical oncology2024

Does autoimmune disease impair the survival of hepatocellular carcinoma patients undergoing liver resection? A multi-institutional observational study.

Chao-Wei Lee, Hsing-Yu Chen, Ping-Han Tsai, Wei-Chen Lee, Chih-Chi Wang, Ming-Chin Yu, Chun-Wei Chen, Po-Ting Lin, Bo-Huan Chen, Sheng-Fu Wang and 2 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cancer research and clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chao-Wei Lee *Division of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan.
Hsing-Yu Chen *College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0001-7897-9851
Ping-Han TsaiDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, New Taipei Municipal Tucheng Hospital, Tu-Cheng, New Taipei City, Taiwan.
Wei-Chen LeeDivision of General Surgery, Department of Surgery, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan.
Chih-Chi WangDivision of General Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Ming-Chin YuCollege of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
Chun-Wei ChenCollege of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
Po-Ting LinCollege of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
Bo-Huan ChenCollege of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
Sheng-Fu WangCollege of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.
Pei-Mei ChaiDepartment of Nursing, Linkou Chang Gung Memorial Hospital, Guishan, Taoyuan, Taiwan.
Hsin-I TsaiCollege of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan. tsaic@hotmail.com.

Funding

Chang Gung Memorial Hospital, Linkou CMRPG3M1701Ministry of Science and Technology, Taiwan, R.O.C. MOST 111-2314-B-182A-122 -/ NMRPG3M0201
6 · The paper itself

Abstract

backgroundPatients with autoimmune diseases (AD) generally carry an increased risk of developing cancer. However, the effect of AD in hepatocellular carcinoma (HCC) patients receiving surgical treatment is uncertain. The present study aimed to investigate the potential influence of AD on the survival of HCC patients undergoing hepatectomies.

methodsOperated HCC patients were identified from the Chang Gung Research Database, and the survival outcomes of HCC patients with or without AD were analyzed ad compared. Cox regression model was performed to identify significant risk factors associated with disease recurrence and mortality.

resultsFrom 2002 to 2018, a total of 5532 patients underwent hepatectomy for their HCC. Among them, 229 patients were identified to have AD and 5303 were not. After excluding cases who died within 30 days of surgery, the estimated median overall survival (OS) was 43.8 months in the AD (+) group and 47.4 months in the AD (-) group (P = 0.367). The median liver-specific survival and disease-free survival (DFS) were also comparable between the two groups. After Cox regression multivariate analysis, the presence of AD did not lead to a higher risk of all-cause mortality, liver-specific mortality, or disease recurrence.

conclusionOur study demonstrated that autoimmune disease does not impair the OS and DFS of HCC patients undergoing liver resections. AD itself is not a risk factor for tumor recurrence after surgery. Patients eligible for liver resections, as a result, should be considered for surgery irrespective of the presence of AD. Further studies are mandatory to validate our findings.

Indexed as

Autoimmune DiseasesCarcinoma, HepatocellularHepatectomyLiver NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesRisk FactorsSurvival RateAutoimmune diseaseChang Gung Research DatabaseHepatocellular carcinomaLiver resection

Identifiers

PMID39031214
PMCPMC11271344

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