Evidence map›Paper›PMID 39030903›Full record

ArticleAging cell2024

Achilles' spear: A new therapeutic target for age-related diseases.

Yang Xuan, Yue Duan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yang XuanThe Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0009-0003-6245-1544
Yue DuanDepartment of Urology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0002-4479-4231

Funding

Natural Science Foundation of Zhejiang Province Y20H270024Zhejiang Traditional Chinese Medicine Administration 2022ZZ017
6 · The paper itself

Abstract

The role of the senescence-associated secretory phenotype (SASP) in the development of age-related diseases is significant, and its control promises to have a tremendous positive impact on health. A recent study has identified a new mechanism for SASP regulation, titled miMOMP. Failure to regulate SASP would dramatically increase the risk of various age-related health problems. Nonetheless, we have not completely comprehended how to modulate SASP. In this commentary, we summarise the specific mechanisms by which miMOMP regulates SASP and outline possible future research directions. Moreover, potential risks and obstacles to the clinical translation of miMOMP are also presented.

Indexed as

AgingAnimalsCellular SenescenceHumansSenescence-Associated Secretory Phenotypeage‐related diseasesmiMOMPmtDNASASP

Identifiers

PMID39030903
PMCPMC11258437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.