Evidence map›Paper›PMID 39030631›Full record

ArticleHuman genomics2024

Genetic distance and ancestry proportion modify the association between maternal genetic risk score of type 2 diabetes and fetal growth.

Tesfa Dejenie Habtewold, Prabhavi Wijesiriwardhana, Richard J Biedrzycki, Fasil Tekola-Ayele

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In one paragraph

Article in Human genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Maternal obesity and ancestry distance in influencing birth outcomes.International journal of obesity (2005) · 2025
    Observational
4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tesfa Dejenie HabtewoldEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, 20892-7004, USA.
Prabhavi WijesiriwardhanaEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, 20892-7004, USA.
Richard J BiedrzyckiGlotech, Inc., contractor for Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, 20892-7004, USA.
Fasil Tekola-AyeleEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, 20892-7004, USA. ayeleft@mail.nih.gov.

Funding

Genetic epidemiology of early growth and cardiometabolic diseasesZIAHD008967 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI TEKOLA-AYELE, FASIL · 2018 to 2025
$4.4M
6 · The paper itself

Abstract

backgroundMaternal genetic risk of type 2 diabetes (T2D) has been associated with fetal growth, but the influence of genetic ancestry is not yet fully understood. We aimed to investigate the influence of genetic distance (GD) and genetic ancestry proportion (GAP) on the association of maternal genetic risk score of T2D (GRS

methodsMulti-ancestral pregnant women (n = 1,837) from the NICHD Fetal Growth Studies - Singletons cohort were included in the current analyses. Fetal weight (in grams, g) was estimated from ultrasound measurements of fetal biometry, and birthweight (g) was measured at delivery. GRS

resultsAmong women with the closest GD from African and Amerindigenous ancestries, the fourth and third GRS

conclusionsThe association between maternal GRS

Indexed as

Birth WeightDiabetes Mellitus, Type 2Fetal DevelopmentGenetic Predisposition to DiseaseGenome-Wide Association StudyAdultFemaleFetal WeightGenetic Risk ScoreHumansPolymorphism, Single NucleotidePregnancyRisk FactorsBirthweightFetal growthFetal weightGenetic ancestry proportionGenetic distanceGenetic risk scoreGenetic similarityType 2 diabetes mellitus

Identifiers

PMID39030631
PMCPMC11264503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.