ArticleLipids in health and disease2024
The association between the triglyceride-glucose index and sarcopenia: data from the NHANES 2011-2018.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of the triglyceride-glucose index with the risk of sarcopenia: a meta-analysis with clinical implications.BMC endocrine disorders · 2026Pooled it
- Associations between the triglyceride‒glucose index and the odds of low muscle mass and sarcopenia: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Pooled it
- Sarcopenia, an independent predictor for all-cause mortality in rheumatoid arthritis: Insights from the NHANES database.Medicine · 2026Article
- Association of frailty index with sarcopenia: Mediation analysis of triglyceride-glucose-related indices: a cross-sectional study.Medicine · 2026Article
- Relationship between triglyceride-glucose index and muscle strength in middle-aged and older Chinese adults without chronic diseases: a nationwide longitudinal cohort study.Scientific reports · 2026Article
- Sustained moderate to high triglyceride-glucose index level is associated with a lower risk of sarcopenia in middle-aged and elderly adults: a nationally representative cohort study.Lipids in health and disease · 2026Article
- Pathological changes and therapeutic strategies for sarcopenia.EFORT open reviews · 2026Review
- Continuous glucose monitoring-derived glycemic variability and low skeletal muscle mass in middle-aged and older adults with type 2 diabetes mellitus: an analysis using AWGS 2025 criteria.Diabetology & metabolic syndrome · 2026Article
- The triglyceride HDL cholesterol ratio predicts sarcopenia risk in an aging National cohort from China.Scientific reports · 2026Article
- Modified cardiometabolic index outperforms conventional indices in discriminating relative muscle loss: a cross-sectional analysis of NHANES 2011-2018.European journal of medical research · 2026Article
- Association of TyG with Survival and Metabolic Alterations in Severe Fever with Thrombocytopenia Syndrome: A Single- Centre Retrospective Study.Infection and drug resistance · 2026Article
- Association between triglyceride-glucose index and sarcopenia in older adults without either dysglycemia or central obesity: a cross-sectional study from CHARLS.Open medicine (Warsaw, Poland) · 2026Article
- Decoding serum C-reactive protein-associated molecular patterns in aging and secondhand smoke exposure chronic obstructive pulmonary disease male patients: evidence from cross-sectional, multi-omic and clinical studies.Frontiers in medicine · 2026Article
- Association of magnesium depletion score, triglyceride-glucose index, and C-reactive protein-albumin-lymphocyte index with diabetic sarcopenia: a cross-sectional study based on NHANES 2014-2018 data.American journal of translational research · 2026Article
- The Role of hs-CRP and Systemic Immune-Inflammation Index in Sarcopenia and Sarcopenic Obesity in Young Populations: Results from the National Health and Nutrition Examination Survey 2015-2018.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Development and validation of a machine learning-based sarcopenia prediction model using the triglyceride glucose-frailty index.The Journal of international medical research · 2026Article
- The Relationship between Sarcopenia and All-Cause and Cardiovascular Mortality Risk among Middle-Aged and Older Adults across Stages 0-3 of Cardiovascular-Kidney-Metabolic Syndrome: Evidence from NHANES and CHARLS.Cardiorenal medicine · 2026Article
- Association of triglyceride-glucose muscle loss index with major adverse cardiovascular events in angina patients: the potential mediating role of inflammation.Frontiers in medicine · 2026Article
- Association between triglyceride-glucose muscle-loss index (TyG-MLI) and incident cardiovascular disease: a prospective cohort study in the UK biobank.Cardiovascular diabetology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Triglyceride-glucose (TyG) index is a marker of insulin resistance, but its role in sarcopenia is controversial. The purpose of this study was to investigate the association of the TyG index with sarcopenia.
methods4030 participants aged 20 years and above were selected from National Health and Nutrition Examination Survey for cross sectional study. Weighted logistic regression model was used to estimate the association between TyG index and sarcopenia. Threshold effect analysis and restricted cubic spline were employed to describe nonlinear link, with interaction tests and subgroup analyses performed.
resultsIt was found in the fully adjusted model that the TyG index was positively associated with sarcopenia (per 1-unit increase in the TyG index: OR = 1.31, 95%CI: 1.07, 1.60). This association was further highlighted in groups characterized by the absence of MetS or diabetes, as well as the absence of vigorous or moderate work activity. Furthermore, analysis of the curve fitting and threshold effects indicated a nonlinear relationship, which exhibited a turning point at 9.14.
conclusionThe study results indicated that the TyG index was positively associated with sarcopenia. Enhancing the management of insulin resistance could help reduce the risk of developing sarcopenia.
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