ArticleJournal of nanobiotechnology2024
Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway.
Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mesenchymal Stem Cell-Derived Extracellular Vesicles and Plant-Derived Nanovesicles as Cell-Free Therapies for Thermal Burn Healing: A Systematic Review of Preclinical Evidence and Delivery Strategies.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Phospholipase C-Delta1 Deletion Impairs Dermal Papilla Cell Function by Disrupting the HIF-1/MAPK Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- hUC-MSC-exosomes deliver Let-7b/7f-5p to dermal papilla cells for a multi-target synergistic treatment of androgenetic alopecia.Journal of nanobiotechnology · 2026Article
- Supercritical COMaterials today. Bio · 2026Article
- Exosomal miRNA-218-5p derived from low-passage dermal papilla cells modulates hair follicle growth and development.Non-coding RNA research · 2026Article
- HmmrResearch (Washington, D.C.) · 2026Article
- Extracellular vesicles in wound healing and scar formation: molecular regulation of macrophages, fibroblasts, and their crosstalk.Frontiers in cell and developmental biology · 2026Review
- Effects of the α-ketoglutaric acid on the performance, hair follicle development and antioxidant capacity of Rex rabbits.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Hemp Seed-Derived Exosomes Protect Against Dihydrotestosterone-Induced Chicken Feather Growth Inhibition.Pharmaceuticals (Basel, Switzerland) · 2025Article
- H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development.Epigenetics & chromatin · 2025Article
- Therapeutic potential of stem cell-derived exosomes in hair regeneration: A systematic review.World journal of stem cells · 2025Article
- Construction of Large-Scale Bioengineered Hair Germs and In Vivo Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing.Journal of nanobiotechnology · 2025Article
- Biocompatible exosomes derived fromRegenerative biomaterials · 2025Article
- Exosome-Based Therapeutics in Dermatology.Biomaterials research · 2025Review
- Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes.Theranostics · 2025Article
- The Potential Application of Exosomes as Therapeutic Agents, Carriers, and Biomarkers in Skin Diseases.International journal of nanomedicine · 2025Review
- Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.Cells · 2024Review
- Review
- Stem cell-based approaches for alopecia: A narrative review of current and emerging treatment strategies.Cell transplantationReview
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Hair follicle (HF) regeneration during wound healing continues to present a significant clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) hold immense potential for inducing HF neogenesis. However, the accurate role and underlying mechanisms of DPC-Exos in HF regeneration in wound healing remain to be fully explained. This study, represents the first analysis into the effects of DPC-Exos on fibroblasts during wound healing. Our findings demonstrated that DPC-Exos could stimulate the proliferation and migration of fibroblasts, more importantly, enhance the hair-inducing capacity of fibroblasts. Fibroblasts treated with DPC-Exos were capable of inducing HF neogenesis in nude mice when combined with neonatal mice epidermal cells. In addition, DPC-Exos accelerated wound re-epithelialization and promoted HF regeneration during the healing process. Treatment with DPC-Exos led to increased expression levels of the Wnt pathway transcription factors β-catenin and Lef1 in both fibroblasts and the dermis of skin wounds. Specifically, the application of a Wnt pathway inhibitor reduced the effects of DPC-Exos on fibroblasts and wound healing. Accordingly, these results offer evidence that DPC-Exos promote HF regeneration during wound healing by enhancing the hair-inducing capacity of fibroblasts and activating the Wnt/β-catenin signaling pathway. This suggests that DPC-Exos may represent a promising therapeutic strategy for achieving regenerative wound healing.
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