Evidence map›Paper›PMID 39030531›Full record

SynthesisBMC cancer2024

Risk factors for esophageal anastomotic stricture after esophagectomy: a meta-analysis.

Yuan Zhong, Ruijuan Sun, Wei Li, Weiqian Wang, Jianpeng Che, Linlin Ji, Bingrong Guo, Chunbo Zhai

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Endoscopic Vacuum Therapy: When and How to Use It?GE Portuguese journal of gastroenterology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuan ZhongDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Ruijuan SunDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Wei LiDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Weiqian WangDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Jianpeng CheDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Linlin JiDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China.
Bingrong GuoSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Chunbo ZhaiDepartment of Thoracic Surgery, Weifang People's Hospital, Weifang, Shandong, China. zhaicbmd@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to assess the risk factors for anastomotic stricture in esophageal cancer patients undergoing esophagectomy. Esophageal anastomotic stricture is the most common long-term complication for esophagectomy. The risk factors for esophageal anastomotic stricture still remain controversial.

methodsMEDLINE, Cochrane Library, and EMBASE were searched to identify observational studies reporting the risk factors for esophageal anastomotic stricture after esophagectomy. A meta-analysis was conducted to investigate the impact of various risk factors on esophageal anastomotic stricture. The GRADE [Grading of Recommendations Assessment, Development and Evaluation] approach was used for quality assessment of evidence on outcome levels.

resultsThis review included 14 studies evaluating 5987 patients.The meta-analysis found that anastomotic leakage (odds ratio [OR]: 2.75; 95% confidence interval[CI]:2.16-3.49), cardiovascular disease [OR:1.62; 95% CI: 1.22-2.16],diabete [OR: 1.62; 95% CI: 1.20-2.19] may be risk factors for esophageal anastomotic stricture.There were no association between neoadjuvant therapy [OR: 0.78; 95% CI:0.62-0.97], wide gastric conduit [OR:0.98; 95% CI: 0.37-2.56],mechanical anastomosis [OR: 0.84; 95% CI:0.47-1.48],colonic interposition[OR:0.20; 95% CI: 0.12-0.35],and transhiatal approach[OR:1.16; 95% CI:0.81-1.64],with the risk of esophageal anastomotic stricture.

conclusionsThis meta-analysis provides some evidence that anastomotic leakage,cardiovascular disease and diabete may be associated with higher rates of esophageal anastomotic stricture.Knowledge about those risk factors may influence treatment and procedure-related decisions,and possibly reduce the anastomotic stricture rate.

Indexed as

Anastomosis, SurgicalEsophageal NeoplasmsEsophageal StenosisEsophagectomyAnastomotic LeakHumansOdds RatioPostoperative ComplicationsRisk FactorsAnastomotic strictureEsophagectomyMeta-analysisRisk factors

Identifiers

PMID39030531
PMCPMC11264988

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.