ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024
Environmental and neurodevelopmental contributors to youth mental illness.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of premature birth and low birth weight on motor, visual, and cognitive skills and mental health in adolescence: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Annual Research Review: Associations of socioeconomic status with cognitive function, language ability, and academic achievement in youth: a systematic review of mechanisms and protective factors.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Multisystem Environmental Factors Elucidate Shared and Distinct Associations With Brain and Behavior in Adolescents.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Neural correlates of resilience to trauma during adolescence: A multi-modal study.JCPP advances · 2026Article
- Associations between transdiagnostic dimensions of psychopathology and brain structure and function in youth: What have we learned from the Adolescent Brain Cognitive Development (ABCD) study?Developmental cognitive neuroscience · 2026Article
- Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mental health trajectory groups: Family income, neighborhood disadvantage, and role of the school environment.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Less is more? A hybrid machine learning and psychometric approach to identifying clinically relevant psychopathology in Chinese youth using the Child Behaviour Checklist.Child and adolescent psychiatry and mental health · 2026Article
- Physical-Digital and social-nonsocial extracurricular engagement: differential effects on brain development and psychological outcomes in children.Translational psychiatry · 2026Article
- Individual differences in adolescent cortical development are associated with neighborhood characteristics: Longitudinal findings from the ABCD study.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Functional heterogeneity in non-suicidal self-injury across psychiatric disorders: neural and psychosocial correlates.Translational psychiatry · 2026Article
- Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Associations between socioeconomic status and mental health trajectories during early adolescence: Findings from the Adolescent Brain Cognitive Development study.JCPP advances · 2025Article
- Early intervention guidelines for infants at risk of neurodevelopmental delay using traditional childcare practices from India.BMJ paediatrics open · 2025Article
- Review
- White matter free water and depressive symptoms in medication-free depressed adolescents: moderation by peripheral inflammation.Translational psychiatry · 2025Article
- The Development of Quality Indicators to Assess Family Wellbeing Outcomes Following Engagement with Children's Mental Health Services in Ontario, Canada.European journal of investigation in health, psychology and education · 2025Article
- Competitive Anxiety, Sports Injury, and Playing Category in Youth Soccer Players.Children (Basel, Switzerland) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While a myriad of factors likely contribute to the development of mental illness in young people, the social environment (including early adverse experiences) in concert with neurodevelopmental alterations is undeniably important. A number of influential theories make predictions about how and why neurodevelopmental alterations may mediate or moderate the effects of the social environment on the emergence of mental illness. Here, we discuss current evidence supporting each of these theories. Although this area of research is rapidly growing, the body of evidence is still relatively limited. However, there exist some consistent findings, including increased striatal reactivity during positive affective processing and larger hippocampal volumes being associated with increased vulnerability or susceptibility to the effects of social environments on internalizing symptoms. Limited longitudinal work has investigated neurodevelopmental mechanisms linking the social environment with mental health. Drawing from human research and insights from animal studies, we propose an integrated mediation-moderation model and outline future research directions to advance the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.