ArticleNature metabolism2024
Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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62citing papers in PubMed, 1 pooled it
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of fecal microbiota transplantation on glycemic and lipid profiles in overweight or obese patients with metabolic disorders: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Revisiting gut microbiota-driven ammonia metabolism: from disease burden to physiological adaptation.Gut microbes · 2026Review
- Artemisinin and its derivatives for metabolic syndrome: From multi‑target mechanisms to translational opportunities (Review).Molecular medicine reports · 2026Review
- Balancing essential amino acids in low-protein diets: Impacts on growth performance, amino acid transport, and cecal microbiota in yellow-feathered chickens.Poultry science · 2026Article
- Marine-Derived Proteins: Individual Variability in Health Effects Across Protein Structure, Host Genetics, and Gut Microbiota.Comprehensive reviews in food science and food safety · 2026Review
- A barrier-centered perspective on the gut-barrier-bone axis: a review of the core role of the intestinal barrier and related probiotics with nanocoatings.Archives of microbiology · 2026Review
- Dietary Bacillus sp. Modulates Multi-tissue Metabolism Through Gut Microbiota Remodeling in High-fat Fed Larimichthys crocea.Probiotics and antimicrobial proteins · 2026Article
- Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.Materials today. Bio · 2026Review
- Mitochondrial STING Governs Glycolytic Reprogramming in Diabetic Cardiomyopathy.Circulation research · 2026Article
- Postbiotic Stool Filtrates From Patients With Type 2 Diabetes Impair Mouse Intestinal Muscle Contractility Ex Vivo and Alter Enteric Cholinergic Neuronal Activity in Vivo.Neurogastroenterology and motility · 2026Article
- Gut microbiome composition and functional potential associate with incident type 2 diabetes in 4,685 adults from a Swedish prospective cohort.Cell reports. Medicine · 2026Article
- Nervonic Acid Prevents HFD-Induced Metabolic Dysfunction and Is Associated with Gut Microbiota Remodeling.Metabolites · 2026Article
- The impact of hydrogen sulfide on gut microbiota of diabetic mice with lower limb arterial ischemia.BMC microbiology · 2026Article
- Effects of dietary zinc fulvate supplementation on egg quality, serum biochemical indices, and intestinal health of aged laying hens.AMB Express · 2026Article
- GLP-1 and Parkinson's Disease: A Comprehensive Review of Biology, Mechanisms and Efficacy.Cells · 2026Review
- Integrated Multi-Omics Analysis Explores the Protective Effects and Potential Mechanisms ofBiomolecules · 2026Article
- Integrated omics reveal the effects of vitamin D deficiency on gut microbiota and plasma metabolism in experimental autoimmune uveitis.Journal of neuroinflammation · 2026Article
- Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice.NPJ science of food · 2026Article
- Bioengineered ROS-tolerant probiotic reshapes gut microbiota-host axis to ameliorate type 2 diabetes in male mice.Nature communications · 2026Article
- HBiochemistry · 2026Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors.
Qingqing Qi *State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-6705-3145
Huijie Zhang *State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-3003-209X
Zheyu Jin *State Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-8006-8974
Changchun WangState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.
Mengyu XiaState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.
Bandy ChenDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Bomin LvState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.
Ludmila Peres DiazDepartment of Immunobiology, Institute for Biomolecular Design and Discovery, Yale University School of Medicine, New Haven, CT, USA.
Xue LiState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-6214-4243
Ru FengRenji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mengdi QiuState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.
Yang LiCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
David MeseguerDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2977-4176
Xiaojiao ZhengCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei WangState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-5539-4532
Wei SongDepartment of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0002-7007-5281
He HuangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2394-0877
Hao WuState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-1314-4954
Lei ChenRenji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. lei.chen@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-7864-8649
Marc SchneebergerDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. marc.schneebergerpane@yale.edu.ORCID http://orcid.org/0000-0001-7369-104X
Xiaofei YuState Key Laboratory of Genetic Engineering, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, China. xiaofei_yu@fudan.edu.cn.ORCID http://orcid.org/0000-0002-1712-331X
Funding
National Natural Science Foundation of China (National Science Foundation of China) 92157110
Abstract
Dysbiosis of the gut microbiota has been implicated in the pathogenesis of metabolic syndrome (MetS) and may impair host metabolism through harmful metabolites. Here, we show that Desulfovibrio, an intestinal symbiont enriched in patients with MetS, suppresses the production of the gut hormone glucagon-like peptide 1 (GLP-1) through the production of hydrogen sulfide (H
Indexed as
Gastrointestinal MicrobiomeGlucagon-Like Peptide 1Hydrogen SulfideAnimalsDesulfovibrioMaleMetabolic SyndromeMiceMice, Inbred C57BLGlucagon-Like Peptide 1Hydrogen Sulfide
Identifiers
PMID
39030389What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.