Evidence map›Paper›PMID 39030379›Full record

ArticleCommunications medicine2024

Mediterranean diet and associations with the gut microbiota and pediatric-onset multiple sclerosis using trivariate analysis.

Ali I Mirza, Feng Zhu, Natalie Knox, Lucinda J Black, Alison Daly, Christine Bonner, Gary Van Domselaar, Charles N Bernstein, Ruth Ann Marrie, Janace Hart and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Mediterranean diet and risk of multiple sclerosis: A prospective cohort study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ali I MirzaDepartment of Medicine (Neurology), The University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-9705-4624
Feng ZhuDepartment of Medicine (Neurology), The University of British Columbia, Vancouver, BC, Canada.
Natalie KnoxNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Lucinda J BlackCurtin School of Population Health, Curtin University, Perth, WA, Australia.
Alison DalyCurtin School of Population Health, Curtin University, Perth, WA, Australia.ORCID http://orcid.org/0000-0002-4919-5932
Christine BonnerNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Gary Van DomselaarNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.
Charles N BernsteinDepartment of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.ORCID http://orcid.org/0000-0001-8041-3574
Ruth Ann MarrieDepartment of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Janace HartDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
E Ann YehDepartment of Pediatrics (Neurology), The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Amit Bar-OrCentre for Neuroinflammation and Experimental Therapeutics and Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7179-0335
Julia O'MahonyDepartment of Pediatrics (Neurology), The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Yinshan ZhaoDepartment of Medicine (Neurology), The University of British Columbia, Vancouver, BC, Canada.
William HsiaoFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Brenda BanwellDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Division of Child Neurology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Emmanuelle WaubantDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Helen TremlettDepartment of Medicine (Neurology), The University of British Columbia, Vancouver, BC, Canada. helen.tremlett@ubc.ca.ORCID http://orcid.org/0000-0001-5804-2535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We aimed to assess the interrelationship between diet, the gut microbiota, and MS.

methodsWe conducted a case-control study including 95 participants (44 pediatric-onset MS cases, 51 unaffected controls) enrolled from the Canadian Pediatric Demyelinating Disease Network study. All had completed a food frequency questionnaire ≤21-years of age, and 59 also provided a stool sample.

resultsHere we show that a 1-point increase in a Mediterranean diet score is associated with 37% reduced MS odds (95%CI: 10%-53%). Higher fiber and iron intakes are also associated with reduced MS odds. Diet, not MS, explains inter-individual gut microbiota variation. Several gut microbes abundances are associated with both the Mediterranean diet score and having MS, and these microbes are potential mediators of the protective associations of a healthier diet.

conclusionsOur findings suggest that the potential interaction between diet and the gut microbiota is relevant in MS.

Identifiers

PMID39030379
PMCPMC11271616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.