ArticleNature chemical biology2025
Lysine L-lactylation is the dominant lactylation isomer induced by glycolysis.
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Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 1 of them a synthesis that pooled it.
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141citing papers in PubMed, 1 pooled it
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Who cites it
141 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The lactate-lactylation axis in renal fibrosis: potential mechanisms in diabetic kidney disease.Annals of medicine · 2025Pooled it
- IntratumorGut microbes · 2026Article
- Lactate Signal: Modulator of Cellular Energy Production and Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review).International journal of molecular medicine · 2026Review
- Post‑translational modification‑governed immune states in cancer immunity: Biomarker implications for checkpoint competence, tumor visibility and immunotherapy resistance (Review).International journal of oncology · 2026Review
- Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases.Clinical and translational medicine · 2026Review
- The lactate-lactylation axis in acute kidney injury: mechanisms from metabolic reprogramming to epigenetic regulation and clinical therapeutic prospects.International urology and nephrology · 2026Review
- Article
- Myelin Dynamics at the Axon-Oligodendrocyte Interface: Adaptive Conduction Homeostasis in Demyelination, Remyelination and White Matter Repair.International journal of molecular sciences · 2026Review
- Lactate-Mediated Lysine Lactylation in Renal Fibrosis: Current Progress and Challenges.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease.Journal of translational medicine · 2026Review
- A lactate-α-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells accelerates tumor progression by inducing NK cell senescence.Nature cancer · 2026Article
- Histone H4 lysine 12 lactylation-driven ZIP14 expression is involved in electroacupuncture therapy against cerebral ischemia/reperfusion injury in mice.Journal of advanced research · 2026Article
- Lactylation: A central metabolic-epigenetic driver of sepsis-associated acute kidney injury.Molecular biology reports · 2026Review
- Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments.Molecular biomedicine · 2026Review
- The Lactate-lactylation circuitry in kidney fibrosis: cellular crosstalk from tubular metabolic reprogramming to macrophage effector functions.Seminars in immunopathology · 2026Review
- Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis.International journal of molecular medicine · 2026Article
- Metabolite and nutrient regulation of macrophages in obesity and metabolic disease.Nature reviews. Immunology · 2026Review
- Lysine l-Lactylation: Bridging Metabolism, Chromatin and Disease.Cell proliferation · 2026Review
- Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
81 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors.
Di Zhang *State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China. zhangdi@pku.edu.cn.ORCID 0000-0002-9341-9884
Jinjun Gao *Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7390-5578
Zhijun Zhu *Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0009-0002-9465-498X
Qianying MaoState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.
Zhiqiang XuNational Clinical Research Center for Geriatrics and General Practice Ward/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Pankaj K SinghLewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Philadelphia, PA, USA.ORCID 0000-0001-9626-5182
Cornelius C RimayiLewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Philadelphia, PA, USA.ORCID 0000-0002-5494-7094
Carlos Moreno-YruelaCenter for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2450-6519
Shuling XuSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0009-0005-3294-4537
Gongyu LiSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-2367-4433
Yi-Cheng SinDepartment of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota at Twin Cities, Minneapolis, MN, USA.ORCID 0000-0002-9876-9197
Yue ChenDepartment of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota at Twin Cities, Minneapolis, MN, USA.
Christian A OlsenCenter for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2953-8942
Nathaniel W SnyderLewis Katz School of Medicine at Temple University, Department of Cardiovascular Sciences, Center for Metabolic Disease Research, Philadelphia, PA, USA.ORCID 0000-0001-5643-8747
Lunzhi DaiNational Clinical Research Center for Geriatrics and General Practice Ward/International Medical Center Ward, General Practice Medical Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. lunzhi.dai@scu.edu.cn.ORCID 0000-0002-3003-8910
Lingjun LiDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA. lingjun.li@wisc.edu.ORCID 0000-0003-0056-3869
Yingming ZhaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. yingming.zhao@uchicago.edu.ORCID 0000-0003-1928-2151
Funding
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7MHistone lactylation pathway in hair cycle: deacylases and their protein targetsR01AR078555 · NIAMS · UNIVERSITY OF CHICAGO · PI LIN, HENING, ZHAO, YINGMING · 2021 to 2025
$3.3MLactate production by tumor associated macrophages promotes tumorigenesisR01CA251677 · NCI · UNIVERSITY OF CHICAGO · PI BECKER, LEV, ZHAO, YINGMING · 2021 to 2025
$2.8MDi-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's diseaseRF1AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$2.4MDiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s diseaseR01AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2023 to 2026
$2.3MAcquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1MQuantification of compartmentalized metabolism in eukaryotic systemsR01GM132261 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI SNYDER, NATHANIEL W. · 2019 to 2023
$1.8MAcquisition of a Dual-Source, High-Performance, Ion Mobility, Quadrupole Time-of-Flight Mass Spectrometry System for Biomedical Research at UW-MadisonS10OD028473 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2021 to 2021
$1.3MMass Spectrometric Studies of Neuropeptides in FeedingR56DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$216kEuropean Science Foundation (ESF) CoG-725172Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) AG052324Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) AR078555Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) CA251677Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) DK071801Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01GM132261Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) S10OD028473Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) S10RR029531National Natural Science Foundation of China (National Science Foundation of China) 32270822National Science Foundation (NSF) CHE-2108223NCI NIH HHS R01 CA251677NCRR NIH HHS S10 RR029531NIAMS NIH HHS R01 AR078555NIA NIH HHS R01 AG052324NIA NIH HHS RF1 AG052324NIDDK NIH HHS R01 DK071801NIDDK NIH HHS R56 DK071801NIGMS NIH HHS R01 GM132261NIH HHS S10 OD028473
Abstract
Lysine L-lactylation (K
Indexed as
GlycolysisLysineProtein Processing, Post-TranslationalChromatography, High Pressure LiquidHistonesHumansIsomerismLactic AcidHistonesLactic AcidLysine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.