Evidence map›Paper›PMID 39030350›Full record

ArticleScientific reports2024

Cell-cycle dependence on the biological effects of boron neutron capture therapy and its modification by polyvinyl alcohol.

Yusuke Matsuya, Tatsuhiko Sato, Tamon Kusumoto, Yoshie Yachi, Ryosuke Seino, Misako Miwa, Masayori Ishikawa, Shigeo Matsuyama, Hisanori Fukunaga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Quantification ofMedicinal research reviews · 2026
    Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yusuke MatsuyaNuclear Science and Engineering Center, Japan Atomic Energy Agency, Tokai, 319-1195, Japan. matsuya.yusuke@hs.hokudai.ac.jp.
Tatsuhiko SatoNuclear Science and Engineering Center, Japan Atomic Energy Agency, Tokai, 319-1195, Japan.
Tamon KusumotoNational Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan.
Yoshie YachiGraduate School of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Ryosuke SeinoGraduate School of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Misako MiwaDepartment of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
Masayori IshikawaFaculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan.
Shigeo MatsuyamaDepartment of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Sendai, 980-8579, Japan.
Hisanori FukunagaFaculty of Health Sciences, Hokkaido University, Sapporo, 060-0812, Japan. hisanori.fukunaga@hs.hokudai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-L-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G

Indexed as

Boron CompoundsBoron Neutron Capture TherapyCell CyclePolyvinyl AlcoholHeLa CellsHumansPhenylalanineBoron CompoundsPhenylalaninePolyvinyl AlcoholBNCTBPACell cycleCR-39 detectorHeavy ionsPVA

Identifiers

PMID39030350
PMCPMC11271528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.