Evidence map›Paper›PMID 39030342›Full record

ArticleNature neuroscience2024

Higher-order interactions between hippocampal CA1 neurons are disrupted in amnestic mice.

Chen Yan, Valentina Mercaldo, Alexander D Jacob, Emily Kramer, Andrew Mocle, Adam I Ramsaran, Lina Tran, Asim J Rashid, Sungmo Park, Nathan Insel and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chen Yan *Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Valentina Mercaldo *Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Alexander D Jacob *Program in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Emily KramerProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Andrew MocleProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Adam I RamsaranProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-3320-0784
Lina TranProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-3504-4524
Asim J RashidProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Sungmo ParkProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Nathan InselProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.
A David RedishDept. of Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3644-9072
Paul W FranklandProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1395-3586
Sheena A JosselynProgram in Neurosciences & Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. Sheena.Josselyn@sickkids.ca.ORCID http://orcid.org/0000-0001-5451-489X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Across systems, higher-order interactions between components govern emergent dynamics. Here we tested whether contextual threat memory retrieval in mice relies on higher-order interactions between dorsal CA1 hippocampal neurons requiring learning-induced dendritic spine plasticity. We compared population-level Ca2

Indexed as

AmnesiaCA1 Region, HippocampalMice, TransgenicNeuronal PlasticityAmyloid beta-PeptidesAnimalsDendritic SpinesMaleMemoryMiceMice, Inbred C57BLNeuronsAmyloid beta-Peptides

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.