Evidence map›Paper›PMID 39030335›Full record

ArticleJournal of hematopathology2024

An unusual case of pure erythroid leukemia with normal karyotype and NPM1 mutation.

Hovsep Ohan, Juan Gomez-Gelvez, Yulei Shen, Sharmila Ghosh, John Carey, Kedar Inamdar, Wei Liu

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In one paragraph

Article in Journal of hematopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hovsep OhanDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Juan Gomez-GelvezDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Yulei ShenDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Sharmila GhoshDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
John CareyDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Kedar InamdarDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
Wei LiuDepartment of Pathology and Laboratory Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA. wliu2@hfhs.org.ORCID http://orcid.org/0000-0003-0377-6384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pure erythroid leukemia (PEL) is an extremely rare subtype of acute myeloid leukemia (AML). Although not specific, PEL is almost uniformly associated with complex karyotype and TP53 mutations. Given the rarity of the disease, our understanding of its cytogenetic and molecular features deems incomplete. We aim to complement existing literature by presenting an unusual case of PEL. The case is comprehensively worked up with multiple modalities. We present for the first time a case of PEL with unusual cytogenetic and molecular features: normal karyotype with absence of TP53 mutations and presence of NPM1 and NRAS mutations. This is a valuable addition to literature, expanding our understanding of molecular and cytogenetic spectra of PEL.

Indexed as

Leukemia, Erythroblastic, AcuteMutationNuclear ProteinsNucleophosminHumansKaryotypeTumor Suppressor Protein p53NPM1 protein, humanNuclear ProteinsNucleophosminTumor Suppressor Protein p53Acute erythroid leukemiaComplex karyotypeProerythroblastsPure erythroid leukemiaTP53 mutation

Identifiers

PMID39030335

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.