ArticleJournal of perinatology : official journal of the California Perinatal Association2024
Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal risk factors associated with neonatal necrotizing enterocolitis: a meta-analysis and systematic review.BMC pediatrics · 2026Pooled it
- Article
- 1-methylnicotinamide attenuated inflammation and regulated flora in Necrotizing enterocolitis.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo identify maternal and neonatal risk factors associated with progression to surgery or death after diagnosis of NEC. STUDY
designForty-seven demographic and clinical factors were evaluated across 216 validated cases of NEC occurring between 2010-2020. Nutrition at NEC onset was evaluated in 149 cases. The binary outcome of surgical NEC (progressing to surgery or death) vs. medical NEC (resolved with antibiotic/bowel rest) was compared across variables.
resultsElevated CRP, rapidly decreasing platelet counts, inotropic medication, intubation, and positive blood cultures within 24 h of diagnosis were associated with progression to surgery/death. Infants with surgical NEC had higher abdominal circumferences at birth. Maternal milk intake and receipt of human milk fortifiers were associated with medical NEC, and infants receiving fortified, maternal milk showed the lowest progression to surgery/death.
conclusionThe index of suspicion should be heightened for surgical NEC when these risk factors are present.
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