ArticleNature communications2024
IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
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35 citing papers in PubMed.
- NOTCH-mediated glial CXCL9:SPP1 polarization by GSK3β exacerbates postnatal enteric nervous system dysfunction in Hirschsprung disease.Journal of gastroenterology · 2026Article
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Oxidative Stress Induced Senescent Macrophage-Driven Squamous Cell Carcinoma Invasion via Glutamine Metabolic Reprogramming.Aging cell · 2026Article
- Neuro-immune interactions in gastrointestinal oncology: Mechanisms, challenges, and therapeutic potential.Innovation (Cambridge (Mass.)) · 2026Review
- Heterogeneity and plasticity of cancer-associated fibroblasts.Nature cancer · 2026Review
- Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Advancements and innovations in the molecular mechanisms and treatment of colorectal cancer.Discover oncology · 2026Review
- Enteric nervous system and inflammatory bowel disease.Gastroenterology report · 2026Review
- SPP1+ Macrophages and the Orchestration of Spatially Organized Immunosuppression in Cancer.Biomedicines · 2026Review
- Targeting macrophage-derived SPP1 enhances CD8 T cell infiltration via ROS-DNA fragment/cGAS-STING/STAT1-mediated CXCL9/10 in tumor microenvironment.Journal for immunotherapy of cancer · 2026Article
- Rab37-mediated OPN secretion enriches SPP1Oncogenesis · 2026Article
- Colorectal cancer organoids: a developmental trajectory from Matrigel embedding to AI-empowered precision medicine.Frontiers in oncology · 2026Review
- Peripheral Nerve-Cancer Interactions in the Tumor Microenvironment: A Three-Dimensional Framework Integrating Mechanisms, Modulators, and Therapeutic Strategies.Research (Washington, D.C.) · 2026Review
- Enteric neuro-immune-tumor ecosystem in pancreatic, colorectal, and gastric malignancies: context dependence and translational priorities.Frontiers in immunology · 2026Review
- From gut microbiota-driven mucosal barrier disruption to myeloid-dominant immunosuppressive niches in colorectal cancer.Frontiers in immunology · 2026Review
- Photobiomodulation mitigates chondrocyte catabolism in osteoarthritis by modulating macrophage M1 polarization through the IL-6/JAK/STAT pathway.Journal of orthopaedic surgery and research · 2025Article
- Gene Therapy in Crohn's Disease: Current Preclinical Challenges and Future Translational Avenues.Biomedicines · 2025Review
- The immune microenvironment of colorectal cancer.Nature reviews. Cancer · 2025Review
- The neuro-immune axis in cancer: from mechanisms to therapeutic opportunities.Journal of hematology & oncology · 2025Review
- The Landscape of SPP1Immunology · 2025Review
Corrections and comments
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Authors and funding
26 authors.
Lies van Baarle *Laboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0001-6708-5350
Veronica De Simone *Laboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Linda Schneider *Department of Surgery, University Hospital Bonn, Medical Faculty, Bonn, Germany.ORCID 0000-0002-9866-4723
Sneha SanthoshLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Saeed AbdurahimanLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Francesca BiscuLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0001-8191-8865
Reiner SchneiderDepartment of Surgery, University Hospital Bonn, Medical Faculty, Bonn, Germany.ORCID 0000-0002-7194-2703
Lisa ZanolettiLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0009-0008-3476-4937
Renata Siqueira de MelloLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0001-7024-5503
Sara VerbandtDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Zedong HuDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Michelle StakenborgLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Bo-Jun KeLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.
Nathalie StakenborgLaboratory for Intestinal Neuro-Immune Interaction, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0002-6229-0045
Raquel Salvador LaureanoCell Stress and Immunity (CSI) Lab, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Balbina García-ReyesDepartment of Surgery, University Hospital Bonn, Medical Faculty, Bonn, Germany.
Jonas HennDepartment of Surgery, University Hospital Bonn, Medical Faculty, Bonn, Germany.ORCID 0000-0001-6608-8381
Marieta TomaDepartment of Pathology, University Hospital Bonn, Medical Faculty, Bonn, Germany.
Maxime VanmechelenTranslational Cell and Tissue Research Unit, Department of Imaging & Pathology, Laboratory for Precision Cancer Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-8342-3150
Guy BoeckxstaensLaboratory for Intestinal Neuro-Immune Interaction, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium.ORCID 0000-0001-8267-5797
Frederik De SmetTranslational Cell and Tissue Research Unit, Department of Imaging & Pathology, Laboratory for Precision Cancer Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-6669-3335
Abhishek D GargCell Stress and Immunity (CSI) Lab, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.ORCID 0000-0002-9976-9922
Sales IbizaLaboratory of Cell Biology & Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Sabine TejparDigestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.ORCID 0000-0003-3281-8643
Sven WehnerDepartment of Surgery, University Hospital Bonn, Medical Faculty, Bonn, Germany. sven.wehner@ukbonn.de.ORCID 0000-0002-8632-7631
Gianluca MatteoliLaboratory of Mucosal Immunology, Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium. gianluca.matteoli@kuleuven.be.ORCID 0000-0002-2902-4976
Funding
EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 833816-NEUMACSEC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 79756-GLIAMACFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 11L0822NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 1S44123NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G067821NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G086721NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G088816NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0A7919NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0B4620NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0D8317NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) S008419NKU Leuven (Katholieke Universiteit Leuven) C12/15/016KU Leuven (Katholieke Universiteit Leuven) C14/17/097KU Leuven (Katholieke Universiteit Leuven) C3 grant, C3/21/037 or C3/23/067Stichting Tegen Kanker (Belgian Foundation Against Cancer) F/2020/1512
Abstract
Enteric glia have been recently recognized as key components of the colonic tumor microenvironment indicating their potential role in colorectal cancer pathogenesis. Although enteric glia modulate immune responses in other intestinal diseases, their interaction with the colorectal cancer immune cell compartment remains unclear. Through a combination of single-cell and bulk RNA-sequencing, both in murine models and patients, here we find that enteric glia acquire an immunomodulatory phenotype by bi-directional communication with tumor-infiltrating monocytes. The latter direct a reactive enteric glial cell phenotypic and functional switch via glial IL-1R signaling. In turn, tumor glia promote monocyte differentiation towards pro-tumorigenic SPP1
Indexed as
Colorectal NeoplasmsNeurogliaSignal TransductionTumor MicroenvironmentAnimalsCell CommunicationCell DifferentiationCell Line, TumorFemaleHumansInterleukin-6MacrophagesMiceMice, Inbred C57BLMonocytesReceptors, Interleukin-1Interleukin-6Receptors, Interleukin-1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.