ArticleNature communications2024
Whole cervix imaging of collagen, muscle, and cellularity in term and preterm pregnancy.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Effect of vaginal delivery history on oliceridine ED₅₀ combined with propofol during painless hysteroscopy: a modified Dixon sequential study.Frontiers in medicine · 2026Trial
- The association between collagenopathies and the risk of spontaneous preterm birth: A systematic review with selective meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Review
- Biomechanical function of the murine cervix with elastic fiber deficiency.Journal of the mechanical behavior of biomedical materials · 2026Article
- Predictive performance of cervical elastography for preterm birth: A head-to-head network meta-analysis.World journal of radiology · 2026Article
- Low-Field Magnetic Resonance Imaging of the Late Gestation Cervix and Birth Outcome Correlation: A Prospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Acromegalic Uteropathy: Specific Uterine Ultrasound Findings in Female Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Evaluation of cervical healing in a rat model using alginate hydrogel embedded with platelet-rich plasma.Molecular biology reports · 2026Article
- Cervical strain elastography improves mid-trimester prediction of spontaneous preterm birth beyond cervical length: a single-center cohort study.Frontiers in medicine · 2026Article
- Female Reproductive Tract Modeling through Advanced 3D Biomimetic Platforms.Biomaterials research · 2026Review
- Predictive value of cervical shear wave elastography combined with cervical morphological parameters for preterm birth after cerclage in patients with cervical insufficiency.Frontiers in medicine · 2026Article
- Review
- Automated cervix biometry, volumetry and normative models for 3D motion-corrected T2-weighted 0.55-3T fetal MRI during 2nd and 3rd trimesters.Scientific reports · 2025Article
- Myxoid Stromal Histophenotype Is Associated with High-Grade and Persistent Cervical Intraepithelial Neoplasia.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.Biology of reproduction · 2025Article
- Whole cervix imaging of collagen, muscle, and cellularity in term and preterm pregnancy.Nature communications · 2024Article
- Establishment and validation of a prognostic model for premature rupture of membranes and preterm delivery in pregnant women after cervical conization.American journal of translational research · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Cervical softening and dilation are critical for the successful term delivery of a fetus, with premature changes associated with preterm birth. Traditional clinical measures like transvaginal ultrasound and Bishop scores fall short in predicting preterm births and elucidating the cervix's complex microstructural changes. Here, we introduce a magnetic resonance diffusion basis spectrum imaging (DBSI) technique for non-invasive, comprehensive imaging of cervical cellularity, collagen, and muscle fibers. This method is validated through ex vivo DBSI and histological analyses of specimens from total hysterectomies. Subsequently, retrospective in vivo DBSI analysis at 32 weeks of gestation in ten term deliveries and seven preterm deliveries with inflammation-related conditions shows distinct microstructural differences between the groups, alongside significant correlations with delivery timing. These results highlight DBSI's potential to improve understanding of premature cervical remodeling and aid in the evaluation of therapeutic interventions for at-risk pregnancies. Future studies will further assess DBSI's clinical applicability.
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Registered trials
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