ArticleCell chemical biology2024
Development of covalent chemogenetic K
Abstract read
In one paragraph
Article in Cell chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels.Channels (Austin, Tex.) · 2026Review
- Expanding the Phenotypic and Functional Evidence for KCNK3 as a Neurodevelopmental Disorder Gene: A New Chinese Case and Drosophila Validation.Clinical genetics · 2026Article
- Structural evidence that a lipid plug controls KNature communications · 2026Article
- Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- Covalent anchoring of tethered ligands to chemogenetic handles for targeted in vivo neuropharmacology.STAR protocols · 2025Article
- Gating mechanism of the two-pore-domain potassium channel THIK1.Nature structural & molecular biology · 2025Article
- Structure of the human KNature structural & molecular biology · 2025Article
- Structure of the human KbioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Update of
Authors and funding
12 authors.
Parker E DealCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Haerim LeeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Abhisek MondalCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Marco LolicatoCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Philipe Ribeiro Furtado de MendonçaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Holly BlackDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Seil JangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Xochina El-HilaliDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Clifford BryantDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Weill Neurohub, University of California, Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA.
Adam R RensloDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 93858-2330, USA. Electronic address: adam.renslo@ucsf.edu.
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA; Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA; Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 93858-2330, USA; California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 93858-2330, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 93858-2330, USA. Electronic address: daniel.minor@ucsf.edu.
Funding
MOLECULAR AND CELLULAR BASIS OF CARDIOVASCULAR DISEASET32HL007731 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 1992 to 2026
$12.4MGenetic and chemical biological studies of K2P structure, function, andmodulationR01MH093603 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2011 to 2026
$8.5MConformational mechanisms of mGluR gating and regulationR01NS119826 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2021 to 2024
$1.6MSynaptic to circuit homeostasis in the Drosophila locomotor systemR01NS107506 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2019 to 2023
$1.6MExpanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo ProbesR01MH116278 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MINOR, DANIEL L, RENSLO, ADAM R · 2018 to 2020
$1.4MNHLBI NIH HHS T32 HL007731NIMH NIH HHS R01 MH093603NIMH NIH HHS R01 MH116278NINDS NIH HHS R01 NS107506NINDS NIH HHS R01 NS119826
Abstract
K
Indexed as
Potassium Channels, Tandem Pore DomainAnimalsHEK293 CellsHumansMembrane PotentialsMiceNeuronsRatsPotassium Channels, Tandem Pore DomainchemogeneticselectrophysiologyK(2P) channelML335potassium channelTREK-1X-ray crystallography
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.