Evidence map›Paper›PMID 39029430›Full record

ArticleComputers in biology and medicine2024

A comprehensive physics-based model for the brachial Artery's full flow mediated dilation (FMD) response observed during the FMD test.

Bchara Sidnawi, Bingjie Zhou, Zhen Chen, Chandra Sehgal, Sridhar Santhanam, Qianhong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computers in biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bchara SidnawiDepartment of Mechanical Engineering, Villanova University, PA, 19085, USA; Cellular Biomechanics and Sport Science Laboratory, Villanova University, PA, 19085, USA.
Bingjie ZhouDepartment of Mechanical Engineering, Villanova University, PA, 19085, USA; Cellular Biomechanics and Sport Science Laboratory, Villanova University, PA, 19085, USA.
Zhen ChenDepartment of Radiology, University of Pennsylvania, PA, 19104, USA.
Chandra SehgalDepartment of Radiology, University of Pennsylvania, PA, 19104, USA.
Sridhar SanthanamDepartment of Mechanical Engineering, Villanova University, PA, 19085, USA.
Qianhong WuDepartment of Mechanical Engineering, Villanova University, PA, 19085, USA; Cellular Biomechanics and Sport Science Laboratory, Villanova University, PA, 19085, USA. Electronic address: qianhong.wu@villanova.edu.

Funding

Flow-mediated dilation by ultrasound imagingR21EB005326 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, CHANDRA M · 2005 to 2006
$431k
NIBIB NIH HHS R21 EB005326
6 · The paper itself

Abstract

In this study, a physics-based model is developed to describe the entire flow mediated dilation (FMD) response. A parameter quantifying the arterial wall's tendency to recover arises from the model, thereby providing a more elaborate description of the artery's physical state, in concert with other parameters characterizing mechanotransduction and structural aspects of the arterial wall. The arterial diameter's behavior throughout the full response is successfully reproduced by the model. Experimental FMD response data were obtained from healthy volunteers. The model's parameters are then adjusted to yield the closest match to the observed experimental response, hence delivering the parameter values pertaining to each subject. This study establishes a foundation based on which future potential clinical applications can be introduced, where endothelial function and general cardiovascular health are inexpensively and noninvasively quantified.

Indexed as

Brachial ArteryModels, CardiovascularVasodilationAdultBlood Flow VelocityFemaleHumansMaleBrachial FMD testFlow mediated dilationFluid-structure interactionMechanotransductionModelWall shear stress

Identifiers

PMID39029430
PMCPMC11324374

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.