Evidence map›Paper›PMID 39028868›Full record

Trial reportJournal of agricultural and food chemistry2024

Identification of Sarmentosin as a Key Bioactive from Blackcurrants (

Dominic Lomiwes, Catrin S Günther, Stephen J Bloor, Tania M Trower, Nayer Ngametua, Alexander P Kanon, Dwayne A Jensen, Kim Lo, Greg Sawyer, Edward G Walker and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of agricultural and food chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The Current State of Knowledge onPlants (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dominic LomiwesThe New Zealand Institute for Plant and Food Research Limited, Palmerston North Campus, 23 Batchelar Road, Fitzherbert, Palmerston North 4410, New Zealand.ORCID 0000-0002-7031-7180
Catrin S GüntherThe New Zealand Institute for Plant and Food Research Limited, Ruakura Campus, Bisley Road, Hamilton 3214, New Zealand.
Stephen J BloorCallaghan Innovation, 69 Gracefield Road, P.O. Box 31310, Lower Hutt 5040, New Zealand.ORCID 0000-0002-1936-5857
Tania M TrowerThe New Zealand Institute for Plant and Food Research Limited, Ruakura Campus, Bisley Road, Hamilton 3214, New Zealand.
Nayer NgametuaThe New Zealand Institute for Plant and Food Research Limited, Palmerston North Campus, 23 Batchelar Road, Fitzherbert, Palmerston North 4410, New Zealand.
Alexander P KanonThe New Zealand Institute for Plant and Food Research Limited, Palmerston North Campus, 23 Batchelar Road, Fitzherbert, Palmerston North 4410, New Zealand.ORCID 0000-0003-2918-1602
Dwayne A JensenThe New Zealand Institute for Plant and Food Research Limited, Ruakura Campus, Bisley Road, Hamilton 3214, New Zealand.
Kim LoThe New Zealand Institute for Plant and Food Research Limited, Auckland Campus, 120 Mount Albert Road, Sandringham, Auckland 1025, New Zealand.
Greg SawyerThe New Zealand Institute for Plant and Food Research Limited, Palmerston North Campus, 23 Batchelar Road, Fitzherbert, Palmerston North 4410, New Zealand.
Edward G WalkerThe New Zealand Institute for Plant and Food Research Limited, Auckland Campus, 120 Mount Albert Road, Sandringham, Auckland 1025, New Zealand.
Duncan HedderleyThe New Zealand Institute for Plant and Food Research Limited, Palmerston North Campus, 23 Batchelar Road, Fitzherbert, Palmerston North 4410, New Zealand.
Janine M CooneyThe New Zealand Institute for Plant and Food Research Limited, Ruakura Campus, Bisley Road, Hamilton 3214, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the efficacy of freeze-dried whole-fruit blackcurrant powder in inhibiting MAO-B compared with blackcurrant juice in healthy adults. Platelet MAO-B inhibition was comparable between powder (89% ± 6) and juice (91% ± 4), and it was positively correlated with MAO-modulated plasma catecholamines, subjective alertness, and reduced mental fatigue, assessed using the Bond-Lader questionnaire. Sarmentosin, a nitrile glycoside, and its hydroxycinnamoyl esters were identified as novel MAO-A/B inhibitors from blackcurrant

Indexed as

Blood PlateletsCross-Over StudiesMonoamine OxidaseMonoamine Oxidase InhibitorsPlant ExtractsRibesAdultDouble-Blind MethodFemaleFruitHumansMaleMiddle AgedYoung AdultMonoamine OxidaseMonoamine Oxidase InhibitorsPlant Extractsbioavailabilityclinical trialfunctional foodin vitromoodneurotransmitter

Identifiers

PMID39028868
PMCPMC11299169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.