Evidence map›Paper›PMID 39028627›Full record

ArticleEnvironmental health perspectives2024

The Association between Exposure to Fine Particulate Matter and MRI-Assessed Locus Coeruleus Integrity in the Vietnam Era Twin Study of Aging (VETSA).

Olivia K Puckett, Christine Fennema-Notestine, Donald J Hagler, Meredith N Braskie, Jiu-Chiuan Chen, Caleb E Finch, Joel D Kaufman, Andrew J Petkus, Chandra A Reynolds, Lauren E Salminen and 5 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Invited Perspective: Blue Skies and Alzheimer's Disease.Environmental health perspectives · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Olivia K PuckettDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Donald J HaglerDepartment of Radiology, University of California San Diego, La Jolla, California, USA.
Meredith N BraskieImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Jiu-Chiuan ChenDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Joel D KaufmanDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Andrew J PetkusDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
Chandra A ReynoldsInstitute for Behavioral Genetics, University of Colorado, Boulder, Boulder, Colorado, USA.
Lauren E SalminenImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Paul M ThompsonImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Xinhui WangDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
William S KremenDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Jeremy A ElmanDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-5840-1769

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2018 to 2022
$11.5M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Genetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8M
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
NIA NIH HHS K01 AG063805NIA NIH HHS P01 AG055367NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838
6 · The paper itself

Abstract

backgroundIncreased exposure to ambient air pollution, especially fine particulate matter

objectiveOur aim was to investigate if exposure to

methodsWe examined the relationship between

resultsMultiple linear regressions revealed a significant association between DISCUSSION: Given previous findings that loss of LC integrity is associated with increased accumulation of AD-related amyloid and tau pathology, impacts on LC integrity may represent a potential pathway through which exposure to air pollution increases AD risk. https://doi.org/10.1289/EHP14344.

Indexed as

Air PollutantsEnvironmental ExposureLocus CoeruleusMagnetic Resonance ImagingParticulate MatterAgedAgingAir PollutionAlzheimer DiseaseHumansMaleMiddle AgedAir PollutantsParticulate Matter

Identifiers

PMID39028627
PMCPMC11259243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.