Evidence map›Paper›PMID 39028500›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Circuit Topology Analysis of Single-Cell HiC Data.

Barbara Scalvini, Alireza Mashaghi

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Barbara ScalviniMedical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, Leiden, The Netherlands.
Alireza MashaghiMedical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, Leiden, The Netherlands. a.mashaghi.tabari@lacdr.leidenuniv.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 3D fold structure of the genome is intricately linked to its function. As a result, descriptors of 3D genome conformation are becoming increasingly important as markers for disease and therapeutic responses. Circuit topology, a theory of folds, formalizes the arrangement of contacts in an entangled chain. It is uniquely suited for the topological description of the cellular genome and changes to genomic architecture during physiological processes like cellular differentiation or pathological and therapeutic alterations. In this discussion, we will explore circuit topology and its ability to extract topological information from single-cell HiC data.

Indexed as

Single-Cell AnalysisChromatinComputational BiologyGenomeGenomicsHumansSoftwareChromatin3D genomeCircuit topologyHiCSingle-cell analysisTopology

Identifiers

PMID39028500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.