ArticleOphthalmology and therapy2024
Detection of Subclinical Neurotrophic Keratopathy by Noncontact Esthesiometry.
Article in Ophthalmology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Validation and Comparative Analysis of a Contemporary Non-Contact Corneal Aesthesiometer.Journal of clinical medicine · 2026Article
- Emerging Technologies in Corneal Nerve Evaluation for Dry Eye and Ocular Surface Disease: A Review.Journal of clinical medicine · 2026Review
- Corneal Sensitivity with the Non-contact Esthesiometer as Compared to the Cotton Wisp Test in Patients with Ocular Surface Diseases.Ophthalmology and therapy · 2026Article
- Impact of Diabetic Peripheral Neuropathy on Corneal Sensitivity and Ocular Surface.Ophthalmic research · 2026Observational
- Clinical Benefits of Preservative-Free Treatment for Glaucoma with a Focus on Preservative-Free Latanoprost.Ophthalmology and therapy · 2025Review
- Evaluation of Corneal Sensitivity: Tools We Have.Diagnostics (Basel, Switzerland) · 2025Review
- Deep Corneal Nerve Plexus Selective Damage in Persistent Neurotrophic Corneal Epithelial Defects Detected by In Vivo Multiphoton Confocal Microscopy.Investigative ophthalmology & visual science · 2025Article
- The Prevalence of Corneal Sensitivity Loss in Patients with and without Dry Eye Disease.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Corneal Nerve Assessment by Aesthesiometry: History, Advancements, and Future Directions.Vision (Basel, Switzerland) · 2024Review
- The THINK Study: Testing Hypoesthesia and the Incidence of Neurotrophic Keratopathy in Cataract Patients with Dry Eye.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
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6 authors.
Funding
Abstract
introductionThis study aimed to analyze corneal sensitivity with a new noncontact and handheld esthesiometer (Brill Engines, Spain) in patients with dry eye disease (DED) and patients on hypotensive drops, and to compare it with healthy subjects.
methodsA total of 31 patients (57 eyes) with DED, 23 patients (46 eyes) with glaucoma, and 21 healthy patients (33 eyes) were recruited. In all patients, corneal sensitivity was measured. Subsequently, a keratography test (Keratograph 5M, Oculus) was carried out to measure tear meniscus height (TMH), non-invasive breakup time (NIBUT), bulbar redness (Jenvis scale), and corneal staining (CS, Oxford scale). Both corneal sensitivity and ocular surface parameters were compared between DED, glaucoma, and healthy subjects. Linear mixed models were constructed to utilize data from both eyes of patients. An alpha level of 0.05 was considered statistically significant.
resultsThe mean age was 56.1 ± 16.1 years in the DED group, 69.5 ± 11.7 years in the glaucoma group, and 37.190 ± 11.677 years in the control group. After adjustment for age and sex, corneal sensitivity was significantly reduced in DED and glaucoma vs control group (P = 0.02 and P = 0.009, respectively). NIBUT was lower in DED and glaucoma groups (P < 0.001 and P = 0.001, respectively). Redness and CS values were higher in the DED group (P = 0.04 and P = 0.001, respectively). TMH was lower in the glaucoma group (P = 0.03).
conclusionsCorneal sensitivity measured with a novel noncontact esthesiometer was reduced in DED and glaucoma groups compared to controls. In clinical practice, this esthesiometer could be an easy-to-use device to screen for patients with subclinical neurotrophic keratopathy.
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