SynthesisEuropean child & adolescent psychiatry2025
Early interventions with parental participation and their implications on the neurodevelopment of premature children: a systematic review and meta-analysis.
Synthesis in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07254780 (Effects of a Treatment Program Based on the Bobath Concept After Hospital Discharge in Children Born Very Preterm), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of a Treatment Program Based on the Bobath Concept After Hospital Discharge in Children Born Very Preterm
Who cites it
18 citing papers in PubMed.
- Retrospective observational study of first-year developmental outcomes following congenital microcephaly.Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- Early Motor Interventions in Infants and Young Children: A Comprehensive Scoping Review.Children (Basel, Switzerland) · 2026Review
- Family: a powerful modifier of outcome.Pediatric research · 2026Article
- Telehealth Delivery of the Homeostasis-Enrichment-Plasticity Approach for Premature Infants With Developmental Risks: Exploratory Feasibility Study.Journal of medical Internet research · 2026Article
- Major clinical improvement in a boy with developmental disabilities and a PTPN4 mutation with intensive re-education and an enriched environment in a day care hospital: a case report.Journal of medical case reports · 2026Article
- A Family-Centered Neurodevelopmental Care Framework for Post-neonatal Intensive Care Unit of Preterm Infants: Delphi Study.Iranian journal of child neurology · 2026Article
- Family-centered early intervention: A concept analysis to guide pediatric and community nursing practice.Belitung nursing journal · 2026Article
- Parental Concerns and Active Participation in Home-Based Vojta Therapy for Children with Global Developmental Delay: A Qualitative Study Using Interviews and Photo-Elicitation.Healthcare (Basel, Switzerland) · 2026Article
- Perceived Control in the NICU: Implications for Maternal Mental Health and Parenting in the NICU.Psychology research and behavior management · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Congenital hypothyroidism and associated visual-motor and intellectual development.Pediatric research · 2025Article
- The shifting landscape of the preterm brain.Neuron · 2025Review
- In-hospital motor interventions to reduce neurodevelopmental impairment in preterm infants: a scoping review.The Cochrane database of systematic reviews · 2025Article
- Application and effect of developmental supportive care on growth and neurobehavioral development in preterm infants.Frontiers in pediatrics · 2025Article
- Effect of home environment on neuropsychiatric development in preterm infants discharged from NICU at 18 months corrected age.General psychiatry · 2025Article
- Analgesia and sedation increases bronchopulmonary dysplasia risk without significant neurodevelopmental impairment in very preterm infants.Frontiers in medicine · 2025Article
- Neurobehavioral disorders among children born to mothers exposed to illicit substances during pregnancy.BMC medicine · 2024Article
- Aggressive and Autoaggressive Behaviors in Patients with Autism Spectrum Disorder in Correlation with Middle Cerebral Artery Flow Velocity.Journal of personalized medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of preterm birth is correlated with the potential emergence of disabilities in children. Early intervention programs are designed to promote better developmental outcomes. These interventions employ family-centered methodologies, wherein parents are instructed to facilitate neurodevelopment, thereby promoting heightened involvement of the child in their daily activities. The objective of this investigation was to evaluate the efficacy of early family-based interventions on motor, cognitive, and language development. A systematic review and meta-analysis was conducted utilizing the databases PubMed, Medline, PEDro, Scopus, CINAHL Complete, SciELO, and Open Grey. The search terms utilized included NDT (neuro-developmental treatment), Bobath, neurodevelopmental therapy, parents administered, family administered, physical therapy modalities, early intervention (educational), early intervention, premature infant, preterm, and premature. Randomized clinical trials and observational studies written in English or Spanish were taken into consideration. The initial search resulted in 420 articles. After removing duplicates and applying the selection criteria, 12 articles were selected for the systematic review and 5 articles were selected for the meta-analysis. The meta-analysis revealed a significant association between early intervention and enhanced cognitive function (p = 0.01) in this study. Additionally, the meta-analysis indicated improvements resulting from early family-based intervention (p = 0.02) in motor function. Early motor interventions that emphasize parent involvement and education in neurodevelopment show significant outcomes in motor and cognitive areas at 2 years of age in very premature or extremely premature infants. However, inconclusive effects have been found in the language area, which is the least studied domain. Due to the methodological heterogeneity observed, further research is needed to establish conclusive decisions regarding the administration of these interventions and the determination of key evaluation periods.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.