Evidence map›Paper›PMID 39028416›Full record

ReviewStem cell reviews and reports2024

Stem Cells in Bone Tissue Engineering: Progress, Promises and Challenges.

Robin Augustine, Mert Gezek, Vasilios K Nikolopoulos, Paige Lauren Buck, Nazli Seray Bostanci, Gulden Camci-Unal

Abstract readReview
In one paragraph

Review in Stem cell reviews and reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Stem Cell Niche Concept: Search for Current Expert Consensus.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Bone Tissue Engineering: From Biomaterials to Clinical Trials.Advances in experimental medicine and biology · 2025
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robin AugustineDepartment of Radiology, Stanford Medicine, Stanford University, Palo Alto, CA, 94304, USA.
Mert GezekDepartment of Chemical Engineering, University of Massachusetts, Lowell, MA, 01854, USA.
Vasilios K NikolopoulosDepartment of Chemical Engineering, University of Massachusetts, Lowell, MA, 01854, USA.
Paige Lauren BuckDepartment of Chemical Engineering, University of Massachusetts, Lowell, MA, 01854, USA.
Nazli Seray BostanciDepartment of Chemical Engineering, University of Massachusetts, Lowell, MA, 01854, USA.
Gulden Camci-UnalDepartment of Chemical Engineering, University of Massachusetts, Lowell, MA, 01854, USA. Gulden_CamciUnal@uml.edu.ORCID 0000-0003-4258-844X

Funding

Scaffolds with high oxygen content for mineralizationR01DE030129 · NIDCR · UNIVERSITY OF MASSACHUSETTS LOWELL · PI CAMCI-UNAL, GULDEN · 2021 to 2025
$2.0M
NIDCR NIH HHS R01 DE030129NIDCR NIH HHS R01DE030129
6 · The paper itself

Abstract

Bone defects from accidents, congenital conditions, and age-related diseases significantly impact quality of life. Recent advancements in bone tissue engineering (TE) involve biomaterial scaffolds, patient-derived cells, and bioactive agents, enabling functional bone regeneration. Stem cells, obtained from numerous sources including umbilical cord blood, adipose tissue, bone marrow, and dental pulp, hold immense potential in bone TE. Induced pluripotent stem cells and genetically modified stem cells can also be used. Proper manipulation of physical, chemical, and biological stimulation is crucial for their proliferation, maintenance, and differentiation. Stem cells contribute to osteogenesis, osteoinduction, angiogenesis, and mineralization, essential for bone regeneration. This review provides an overview of the latest developments in stem cell-based TE for repairing and regenerating defective bones.

Indexed as

Bone and BonesBone RegenerationTissue EngineeringAnimalsCell DifferentiationHumansOsteogenesisStem CellsTissue ScaffoldsBone defectsBone tissue engineeringHydrogelsiPSCsMesenchymal stem cellsOsteogenesis

Identifiers

PMID39028416
PMCPMC13135464

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.