Evidence map›Paper›PMID 39028344›Full record

ArticleAnalytical and bioanalytical chemistry2024

Quantifying non-transferrin-bound iron (NTBI) in human plasma: incorporating BODIPY-pyridylhydrazone (BODIPY-PH) within a thin green film linked to a portable fluorescence-based device.

Puttaraksa Naksen, Kantapat Chansaenpak, Siriporn Jungsuttiwong, Ratchadaree Intayot, Jaroon Jakmunee, Somkid Pencharee, Peter Lieberzeit, Purim Jarujamrus

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Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Puttaraksa NaksenDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
Kantapat ChansaenpakNational Nanotechnology Center, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand.
Siriporn JungsuttiwongCenter for Organic Electronic and Alternative Energy, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Warinchumrap, Ubon Ratchathani, 34190, Thailand.
Ratchadaree IntayotCenter for Organic Electronic and Alternative Energy, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Warinchumrap, Ubon Ratchathani, 34190, Thailand.
Jaroon JakmuneeDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50000, Thailand.
Somkid PenchareeDepartment of Physics, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
Peter LieberzeitDepartment of Physical Chemistry, Faculty for Chemistry, University of Vienna, Waehringer Strasse 42, Vienna, 1090, Austria.
Purim JarujamrusDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand. purim.j@ubu.ac.th.ORCID http://orcid.org/0000-0002-0666-150X

Funding

The National Research Council of Thailand N11A650144
6 · The paper itself

Abstract

Free iron in human serum or non-transferrin-bound iron (NTBI) can generate free radicals and lead to oxidative damage. Moreover, it is highly toxic to various tissues and a vital biomarker related to the iron-loading status of thalassemia and Alzheimer's patients. In NTBI in healthy individuals, NTBI levels are typically less than 1 µM; current NTBI analysis usually requires advanced instrumentation and many-step sample pretreatment. To address this issue, we employed our invented BODIPY derivative, BODIPY-PH, as a fluorescence probe and trapped it onto the microcentrifuge tube lid using tapioca starch. The fluorescence intensity of BODIPY-PH increased with increasing NTBI concentration (turn-on). The developed portable reaction chamber facilitates rapid analysis (∼5 min) using small sample volumes (10 μL sample in a total volume of 600 μL). Under optimum conditions, using the sample-developed portable fluorescence device and fluorescence spectrometer, we achieved impressive limits of detection (LOD) of 0.003 and 0.0015 μM, respectively. Furthermore, the developed sensors show relatively high selectivity toward Fe

Indexed as

Boron CompoundsFluorescent DyesIronLimit of DetectionSpectrometry, FluorescenceHumansHydrazonesTransferrin4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBoron CompoundsFluorescent DyesHydrazonesIronTransferrinBODIPY-pyridylhydrazone (BODIPY-PH)Free ironHuman serumNon-transferrin-bound iron (NTBI)Portable fluorometerThalassemia

Identifiers

PMID39028344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.