ReviewEuropean heart journal2024
Left atrial appendage closure for stroke prevention in atrial fibrillation: current status and perspectives.
Review in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07260474 (Comparison of the Amplatzer Amulet Versus LAmbre Device for Left Atrial Appendage Closure), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Amplatzer Amulet Versus LAmbre Device for Left Atrial Appendage Closure: the CALAMBRE Randomized Clinical Trial
Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Long-term efficacy and safety of left atrial appendage closure vs. oral anticoagulation in atrial fibrillation: a meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Pooled it
- Antithrombotic strategies and DOAC dosing following left atrial appendage occlusion: a network meta-analysis.European heart journal. Cardiovascular pharmacotherapy · 2026Pooled it
- 'One Stop' Therapy has a Satisfying Performance on AF Patients with Interatrial Communication: Evidence from Pooled Clinical Experience.Reviews in cardiovascular medicine · 2025Pooled it
- Surgical left atrial appendage occlusion in valvular heart disease without atrial fibrillation: the OPINION trial.European heart journal · 2026Trial
- Patterns of antithrombotic treatment after left atrial appendage occlusion.Heart rhythm · 2026Article
- WATCHMAN and Amplatzer Amulet for left atrial appendage occlusion: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Article
- Impact of end-stage renal disease on stroke risk in patients with atrial fibrillation.Heart rhythm O2 · 2026Article
- Review
- Severe orthostatic hypotension after left atrial appendage occlusion.HeartRhythm case reports · 2026Article
- Bailout left atrial appendage occlusion as a salvage strategy for acute cardiac tamponade.HeartRhythm case reports · 2026Article
- Advances of Fully Biodegradable Poly-p-Dioxanone and Polylactic Acid-Based Polymers as Left Atrial Appendage Closure Devices.Macromolecular bioscience · 2026Review
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Gigantic rare left atrial appendage with four lobes closed using a watchman FLX and LAmbre closure device in the kissing technique: a case report.European heart journal. Case reports · 2026Article
- Assessing left atrial appendage sealing after interventional closure: how complete is complete?Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Left atrial appendage occluder thrombosis caused embolic strokes: a case report.European heart journal. Case reports · 2026Article
- Intracardiac Versus Transesophageal Echocardiography for Left Atrial Appendage Occlusion: A Meta-Analysis.JACC. Advances · 2026Article
- The ABC of sealing following left atrial appendage closure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Observational
- Long-Term Outcomes With and Without Anticoagulation After Surgical Left Atrial Appendage Amputation or Closure.JACC. Asia · 2026Article
- Development and Validation of a Coronary Computed Tomography Angiography-Based Radiomics-Integrated Model for Noninvasive Detection of Left Atrial Appendage Thrombus in Atrial Fibrillation.Journal of the American Heart Association · 2026Article
- Concomitant left atrial appendage exclusion during cardiac surgery: a single-center case series on technique profile, residual flow, and early safety.Journal of cardiothoracic surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) is associated with an increased risk of stroke and systemic embolism, and the left atrial appendage (LAA) has been identified as a principal source of thromboembolism in these patients. While oral anticoagulation is the current standard of care, LAA closure (LAAC) emerges as an alternative or complementary treatment approach to reduce the risk of stroke or systemic embolism in patients with AF. Moderate-sized randomized clinical studies have provided data for the efficacy and safety of catheter-based LAAC, largely compared with vitamin K antagonists. LAA device iterations, advances in pre- and peri-procedural imaging, and implantation techniques continue to increase the efficacy and safety of LAAC. More data about efficacy and safety of LAAC have been collected, and several randomized clinical trials are currently underway to compare LAAC with best medical care (including non-vitamin K antagonist oral anticoagulants) in different clinical settings. Surgical LAAC in patients with AF undergoing cardiac surgery reduced the risk of stroke on background of anticoagulation therapy in the LAAOS III study. In this review, we describe the rapidly evolving field of LAAC and discuss recent clinical data, ongoing studies, open questions, and current limitations of LAAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.