ReviewFrontiers in veterinary science2024
Male animal sterilization: history, current practices, and potential methods for replacing castration.
Review in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The LAST Mile: Evaluating Genetic Biocontrol as a Supplemental Tool for Eradicating Invasive Rodents on Islands.Evolutionary applications · 2026Article
- Comparing the efficacy of dextrose, mannitol, and saline solutions in male rabbits' chemical castration.Animal models and experimental medicine · 2026Article
- A Novel GnRH-Based Immunocastration Vaccine Modulates Growth, Reproductive and Meat Quality Traits in Male Leizhou Goats.Animals : an open access journal from MDPI · 2026Article
- Regulatory Mechanisms and Safety Evaluation of Exogenous Progesterone for Suppression of Rutting Behavior in Male Sika Deer (Animals : an open access journal from MDPI · 2026Article
- A Comparative Analysis of Intratesticular Versus Intra-Epididymal Injections of Clove Essential Oil on Male Dog Sterilization.Veterinary medicine and science · 2026Article
- Assessing the welfare of dogs surgically sterilized during single day free community pet clinics in Kampala Metropolitan area, Central Uganda.Animal welfare (South Mimms, England) · 2026Article
- Preliminary insights into intratesticular and intraepididymal administration of eugenol: histological alterations and impact on sperm motility in Wistar rats.Animal reproduction · 2026Article
- Efficacy of zinc oxide nanoparticles in chemical castration of male Wistar rats.Scientific reports · 2025Article
- Quality of Meat and Fat from Immunocastrated Boars and Uncastrated Boars Slaughtered at Different Body Weights.Animals : an open access journal from MDPI · 2025Article
- Ultrasonographic Appearance of the Deferent Ducts in Dogs without Genitourinary Disease.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2025Article
- Impact of Burdizzo and Surgical Castration on Immune and Oxidative Stress Markers in Cattle.Veterinary sciences · 2025Article
- High awareness, low compliance: rabies knowledge and dog ownership practices among pastoralists, Marsabit County, Kenya.Frontiers in veterinary science · 2025Article
- Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sterilization and castration have been synonyms for thousands of years. Making an animal sterile meant to render them incapable of producing offspring. Castration or the physical removal of the testes was discovered to be the most simple but reliable method for managing reproduction and sexual behavior in the male. Today, there continues to be global utilization of castration in domestic animals. More than six hundred million pigs are castrated every year, and surgical removal of testes in dogs and cats is a routine practice in veterinary medicine. However, modern biological research has extended the meaning of sterilization to include methods that spare testis removal and involve a variety of options, from chemical castration and immunocastration to various methods of vasectomy. This review begins with the history of sterilization, showing a direct link between its practice in man and animals. Then, it traces the evolution of concepts for inducing sterility, where research has overlapped with basic studies of reproductive hormones and the discovery of testicular toxicants, some of which serve as sterilizing agents in rodent pests. Finally, the most recent efforts to use the immune system and gene editing to block hormonal stimulation of testis function are discussed. As we respond to the crisis of animal overpopulation and strive for better animal welfare, these novel methods provide optimism for replacing surgical castration in some species.
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