Evidence map›Paper›PMID 39027721›Full record

ArticleBJA open2024

Changes of pulse wave transit time after haemodynamic manoeuvres in healthy adults: a prospective randomised observational trial (PWTT volunteer study).

Johannes M Wirkus, Fabienne Goss, Matthias David, Erik K Hartmann, Kimiko Fukui, Irene Schmidtmann, Eva Wittenmeier, Gunther J Pestel, Eva-Verena Griemert

Abstract read
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In one paragraph

Article in BJA open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Johannes M WirkusDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Fabienne GossDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Matthias DavidDepartment of Anaesthesiology, Marienhaus Hospital, Mainz, Germany.
Erik K HartmannDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Kimiko FukuiDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Irene SchmidtmannInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Eva WittenmeierDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Gunther J PestelDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Eva-Verena GriemertDepartment of Anaesthesiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pulse wave transit time (PWTT) shows promise for monitoring intravascular fluid status intraoperatively. Presently, it is unknown how PWTT mirrors haemodynamic variables representing preload, inotropy, or afterload. Methods: PWTT was measured continuously in 24 adult volunteers. Stroke volume was assessed by transthoracic echocardiography. Volunteers underwent four randomly assigned manoeuvres: 'Stand-up' (decrease in preload), passive leg raise (increase in preload), a 'step-test' (adrenergic stimulation), and a 'Valsalva manoeuvre' (increase in intrathoracic pressure). Haemodynamic measurements were performed before and 1 and 5 min after completion of each manoeuvre. Correlations between PWTT and stroke volume were analysed using the Pearson correlation coefficient. Results: 'Stand-up' caused an immediate increase in PWTT (mean change +55.9 ms, Conclusion: Noninvasive assessment of PWTT shows promise to register immediate preload changes in healthy adults. The clinical usefulness of PWTT may be hampered by late changes because of reasons different from fluid shifts. Clinical trial registration: German clinical trial register (DRKS, ID: DRKS00031978, https://www.drks.de/DRKS00031978).

Indexed as

fluid responsivenessfluid resuscitationhaemodynamic monitoringpulse wave transit timestroke volume assessment

Identifiers

PMID39027721
PMCPMC11255098

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.