Evidence map›Paper›PMID 39027344›Full record

ArticleJournal of orthopaedic translation2024

Roles of Sp7 in osteoblasts for the proliferation, differentiation, and osteocyte process formation.

Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin and 1 more

Abstract read
In one paragraph

Article in Journal of orthopaedic translation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  3. Marine drugs · 2026
    Article
  4. Article
  5. Preserved bone mineral density in autosomal dominant SP7-related osteogenesis imperfecta: a case report of the p.Glu340Ala variant.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Epigenetic Regulation ofInternational journal of molecular sciences · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Regulation of Skeletal Development and Maintenance by Runx2 and Sp7.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qing JiangInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou 215006, China.
Kenichi NaganoDepartment of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Takeshi MoriishiDepartment of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Hisato KomoriDepartment of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Chiharu SakaneResearch Center for Biomedical Models and Animal Welfare, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8588, Japan.
Yuki MatsuoDepartment of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Zhiguo ZhangInstitute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Riko NishimuraDepartment of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan.
Kosei ItoDepartment of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Xin QinInstitute of Orthopaedics, Suzhou Medical College, Soochow University, Suzhou 215006, China.
Toshihisa KomoriDepartment of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Zinc finger-containing transcription factor Osterix/Specificity protein-7 (Sp7) is an essential transcription factor for osteoblast differentiation. However, its functions in differentiated osteoblasts remain unclear and the effects of osteoblast-specific Methods: Results: Femoral trabecular bone volume was higher in female Conclusions: Our studies indicated that Sp7 inhibits the proliferation of immature osteoblasts, induces osteoblast maturation and The translational potential of this article: This study clarified the roles of Sp7 in differentiated osteoblasts in proliferarion, maturation,

Indexed as

Cortical porosityOsteoblast differentiationOsteoblast proliferationOsteocyte apoptosisOsteocyte processesSp7

Identifiers

PMID39027344
PMCPMC11254841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.