ReviewTaiwan journal of ophthalmology
Changes in retinal nerve fiber layer, ganglion cell complex, and ganglion cell layer thickness in thyroid eye disease: A systematic review.
Review in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Retinal hemodynamics and oxygen metabolism: potent inflammatory indicators for thyroid eye disease.BMC ophthalmology · 2026Article
- Case Report: Marked bilateral optic disc edema as the presenting manifestation of thyroid eye disease with dysthyroid optic neuropathy.Frontiers in ophthalmology · 2026Article
- Multimodal optical coherence tomography and angiography and serologic markers for accurate early diagnosis of dysthyroid optic neuropathy.American journal of translational research · 2026Article
- Spectral-domain optical coherence tomography imaging findings in patients receiving teprotumumab for thyroid eye disease.American journal of ophthalmology case reports · 2025Article
- Retinal and Choroidal Alterations in Thyroid-Associated Ophthalmopathy: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Evaluation of retinal nerve fiber and ganglion cell layer abnormalities using optical coherence tomography in thyroid-associated orbitopathy.Arquivos brasileiros de oftalmologia · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Thyroid eye disease (TED) is characterized by progressive orbital inflammation. In severe cases, it can lead to dysthyroid optic neuropathy (DON), involving death of retinal ganglion cells and permanent vision loss. Imaging with optical coherence tomography (OCT) has enabled noninvasive examination of the structural impact of the disease, including of the retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), and the inner plexiform layer (IPL). In this study, we systematically review 20 studies (897 patients, 1430 eyes) to evaluate changes in retinal thickness in patients with TED, stratified by severity. Most studies found a decrease in thickness in peripapillary RNFL (pRNFL), non-pRNFL, combined RNFL/GCL/IPL, or combined GCL/IPL when comparing patients with DON to healthy controls or to patients without DON. However, results were equivocal regarding differences between non-DON TED patients and controls. In addition, several studies reported a postoperative decrease in pRNFL thickness after orbital decompression surgery. Future studies examining OCT changes of retinal thickness along with disease progression are needed to assess the potential of OCT in diagnosis and management of patients with TED.
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