Evidence map›Paper›PMID 39026868›Full record

ArticlebioRxiv : the preprint server for biology2024

Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation.

Michael O Isei, Meredith Crockett, Emily Chen, Joel Rodwell-Bullock, Trae Caroll, Peter A Girardi, Keith Nehrke, Gail Vw Johnson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Michael O IseiUniversity of Rochester, Department of Anesthesiology & Perioperative Medicine, Rochester, New York, USA.
Meredith CrockettUniversity of Rochester, Department of Anesthesiology & Perioperative Medicine, Rochester, New York, USA.
Emily ChenUniversity of Rochester, Department of Anesthesiology & Perioperative Medicine, Rochester, New York, USA.
Joel Rodwell-BullockUniversity of Rochester, Department of Anesthesiology & Perioperative Medicine, Rochester, New York, USA.
Trae CarollUniversity of Rochester, Department of Medicine, Nephrology Division, Rochester, New York, USA.
Peter A GirardiUniversity of Rochester, Department of Anesthesiology & Perioperative Medicine, Rochester, New York, USA.
Keith NehrkeUniversity of Rochester, Department of Medicine, Nephrology Division, Rochester, New York, USA.
Gail Vw JohnsonUniversity of Rochester, Department of Anesthesiology & Perioperative Medicine, Rochester, New York, USA.ORCID 0000-0003-3464-0404

Funding

Tau Post-Translational Modifications and Mitochondrial Quality ControlR01AG067617 · NIA · UNIVERSITY OF ROCHESTER · PI JOHNSON, GAIL V. W., NEHRKE, KEITH · 2020 to 2024
$2.9M
NIA NIH HHS R01 AG067617
6 · The paper itself

Abstract

Neurodegenerative diseases are often characterized by mitochondrial dysfunction. In Alzheimer's disease, abnormal tau phosphorylation disrupts mitophagy, a quality control process through which damaged organelles are selectively removed from the mitochondrial network. The precise mechanism through which this occurs remains unclear. Previously, we showed that tau which has been mutated at Thr-231 to glutamic acid to mimic an Alzheimer's-relevant phospho-epitope expressed early in disease selectively inhibits oxidative stress-induced mitophagy in

Indexed as

mitophagy receptorsoxidative stressphosphomimeticsTau phosphorylation

Identifiers

PMID39026868
PMCPMC11257429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.